CANDIDA-ALBICANS HYPHAL FORM ENHANCES TUMOR-NECROSIS-FACTOR MESSENGER-RNA LEVELS AND PROTEIN SECRETION IN MURINE ANA-1 MACROPHAGES

被引：19

作者：

BLASI, E

PITZURRA, L

PULITI, M

BARTOLI, A

BISTONI, F

机构：

[1] Department of Experimental Medicine and Biochemical Sciences, Microbiology Section, University of Perugia, Perugia

来源：

CELLULAR IMMUNOLOGY | 1992年 / 142卷 / 01期

关键词：

D O I：

10.1016/0008-8749(92)90275-T

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have demonstrated that Candida albicans in its hyphal form (H-Candida) acts as a stimulating agent in the cloned macrophage population ANA-1. Both tumor necrosis factor (TNF) mRNA levels and secreted biological activity augment in ANA-1 macrophages exposed to H-Candida. Such effects are observed at an effector-to-target cell ratio of 1:1 and occur after 1 and 3 hr of coincubation, respectively. The phenomenon is independent of the metabolic status of the fungus, since viable as well as heat-killed H-Candida are comparable in inducing TNF mRNA levels. The extent and kinetics of H-Candida-mediated effects are similar to those observed following exposure of ANA-1 macrophages to lipopolysaccharide (LPS). This implies that C. albicans in its hyphal form is a potent macrophage modulator; whether it acts through the same mechanism(s) as LPS remains to be elucidated. © 1992.

引用

页码：137 / 144

页数：8

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