TNF-ALPHA SUPPRESSES CR3-MEDIATED MYELIN REMOVAL BY MACROPHAGES

被引：33

作者：

BRUCK, W

BRUCK, Y

FRIEDE, RL

机构：

[1] Department of Neuropathology, University of Göttingen, Göttingen

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1992年 / 38卷 / 1-2期

关键词：

MYELIN PHAGOCYTOSIS; MACROPHAGE; COMPLEMENT RECEPTOR TYPE-3; TUMOR NECROSIS FACTOR-ALPHA (TNF-ALPHA);

D O I：

10.1016/0165-5728(92)90085-Y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mononuclear cells of the monocyte/macrophage system play an important role in myelin ingestion during Wallerian degeneration. The present in vitro study clarifies the role in this process of two macrophage-secreted cytokines, TNF-alpha and interleukin-1. Treatment with TNF-alpha massively reduced the amount of myelin ingested by macrophages via their complement receptor type 3 (CR3). Anti-TNF-alpha antibodies reversed the effect. Immunofluorescence of macrophages indicated that TNF-alpha caused a reduced expression of the CR3 by phagocytic cells. Further experiments revealed an interaction of TNF-alpha with its receptor on the macrophage cell membrane. Interleukin-1 had no effect on myelin ingestion in the in vitro system used in these experiments.

引用

页码：9 / 17

页数：9

共 34 条

[1] ANTAGONISTIC AND ADDITIVE EFFECTS OF IL-4 AND INTERFERON-GAMMA ON HUMAN MONOCYTES AND MACROPHAGES - EFFECTS ON FC-RECEPTORS, HLA-D ANTIGENS, AND SUPEROXIDE PRODUCTION [J].