(S)-N-(N-(((2R, 3S, 4R, 5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)sulfamoyl)-5-oxopyrrolidine-2-carboxamide

被引：1

作者：

Khaybullin, Ravil N. ^{[1
]}

Liang, Xiao ^{[1
]}

Qi, Xin ^{[1
]}

机构：

[1] Univ Florida, Coll Pharm, Dept Med Chem, Gainesville, FL 32610 USA

来源：

MOLBANK | 2015年 / 02期

关键词：

aminoacyl sulfamide; tRNA synthetase inhibitor; pGlu-SA;

D O I：

10.3390/M864

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aminoacyl sulfamides represent a family of high-affinity inhibitors of the specific aminoacyl tRNA synthetase activity. In this paper we describe the synthesis of a novel sulfamide adenosine derivative 4 bearing pyroglutamyl fragment (pGlu-SA).

引用

页数：7

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