ELECTROCHEMICAL OXIDATION OF HYDROXYLATED PHENOTHIAZINE AND IMIPRAMINE DERIVATIVES

被引：12

作者：

NEPTUNE, M

MCCREERY, RL

MANIAN, AA

机构：

[1] OHIO STATE UNIV,DEPT CHEM,COLUMBUS,OH 43210

[2] NIMH,PSYCHOPHARMACOL RES BRANCH,ROCKVILLE,MD 20857

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 02期

关键词：

D O I：

10.1021/jm00188a014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The electrochemical oxidations of several hydroxylated derivatives of promazine, chlorpromazine, imipramine, and 3-chloroimipramine are examined and compared. Oxidation of the monohydroxyphenothiazine derivatives leads to both dihydroxy species and substituted benzoquinones, while oxidation of hydroxylated imipramines leads to only the corresponding benzoquinones. The oxidation potentials of 17 tricyclic psychoactive drugs and metabolites are tabulated and compared. The potential importance of these results to drug activity and side effects is discussed. © 1979, American Chemical Society. All rights reserved.

引用

页码：196 / 199

页数：4

共 29 条

[1]

ADAMS HR, 1974, PHENOTHIAZINES STRUC, P281

[2]

Adams R. N., 1969, ELECTROCHEMISTRY SOL

[3] INTRACYCLIZATION RATES OF 6-HYDROXYDOPAMINE AND 6-AMINODOPAMINE ANALOGS UNDER PHYSIOLOGICAL CONDITIONS [J].