Severity Of Vascular Disaggregation Effects On Erythrocytes In Patients With Arterial Hypertension With Abdominal Obesity And Dyslipidemia.

The high incidence of thrombosis in patients with arterial hypertension with abdominal obesity and dyslipidemia is caused by the development of pronounced vasopathy in them. Given the high prevalence in the world of a combination of arterial hypertension with abdominal obesity and dyslipidemia, it was important to assess the vascular disaggregation effects on erythrocytes in this category of patients. The aim of the work is to evaluate the disaggregation effects of blood vessels on erythrocytes in patients with arterial hypertension with abdominal obesity and dyslipidemia. 47 patients with arterial hypertension of 1-2 degrees with abdominal obesity and dyslipidemia of the second adulthood were examined. Control is represented by 26 healthy volunteers of the second adult age. The study was performed using biochemical, hematological and statistical methods of investigation. Patients under observation showed an increase in cholesterol in erythrocyte membranes, a decrease in phospholipids in them, and an increase in lipid peroxidation. In patients, spontaneous aggregation of erythrocytes was found to increase. At the same time, they showed a decrease in vascular disaggregation control over red blood cells. We can assume that the weakening of disaggregating vascular effects on erythrocytes is a consequence of metabolic abnormalities that arisen in arterial hypertension with abdominal obesity and dyslipidemia, severe vasospasm and excess lipid peroxidation. The existing vasopathy in these patients increases their risk of thrombosis, which can lead to disability or death.