CLONING AND SEQUENCE OF THE BORDETELLA-BRONCHISEPTICA ADENYLATE CYCLASE-HEMOLYSIN-ENCODING GENE - COMPARISON WITH THE BORDETELLA-PERTUSSIS GENE

被引：16
作者：
BETSOU, F
SISMEIRO, O
DANCHIN, A
GUISO, N
机构：
[1] INST PASTEUR, UNITE BACTERIOL MOLEC & MED, F-75724 PARIS 15, FRANCE
[2] INST PASTEUR, UNITE REGULAT EXPRESS GENET, F-75724 PARIS 15, FRANCE
来源：
GENE | 1995年 / 162卷 / 01期
关键词：
VIRULENCE; PATHOGEN; RTX TOXIN; PROTECTIVE ANTIGEN;
D O I：
10.1016/0378-1119(95)00339-8
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The cyaA gene from Bordetella bronchiseptica (Bb), encoding the adenylate cyclase-hemolysin (AC-Hly), has been cloned and its complete nucleotide sequence has been determined. The deduced amino-acid sequence was compared to the AC-Hly from B. pertussis (Bp) and the main differences were found in the C-terminal repeat region of the molecule.
引用
收藏
页码：165 / 166
页数：2
相关论文
共 10 条
[1]   CYAC-MEDIATED ACTIVATION IS IMPORTANT NOT ONLY FOR TOXIC BUT ALSO FOR PROTECTIVE ACTIVITIES OF BORDETELLA-PERTUSSIS ADENYLATE CYCLASE-HEMOLYSIN [J].
BETSOU, F ;
SEBO, P ;
GUISO, N .
INFECTION AND IMMUNITY, 1993, 61 (09) :3583-3589
[2]   CLONING AND EXPRESSION OF MOUSE-BRAIN CALMODULIN AS AN ACTIVATOR OF BORDETELLA-PERTUSSIS ADENYLATE-CYCLASE IN ESCHERICHIA-COLI [J].
DANCHIN, A ;
SEZER, O ;
GLASER, P ;
CHALON, P ;
CAPUT, D .
GENE, 1989, 80 (01) :145-149
[3]   THE CALMODULIN-SENSITIVE ADENYLATE-CYCLASE OF BORDETELLA-PERTUSSIS - CLONING AND EXPRESSION IN ESCHERICHIA-COLI [J].
GLASER, P ;
LADANT, D ;
SEZER, O ;
PICHOT, F ;
ULLMANN, A ;
DANCHIN, A .
MOLECULAR MICROBIOLOGY, 1988, 2 (01) :19-30
[4]   VIRULENCE OF BORDETELLA-BRONCHISEPTICA - ROLE OF ADENYLATE CYCLASE-HEMOLYSIN [J].
GUEIRARD, P ;
GUISO, N .
INFECTION AND IMMUNITY, 1993, 61 (10) :4072-4078
[5]   INTERNAL LYSINE PALMITOYLATION IN ADENYLATE-CYCLASE TOXIN FROM BORDETELLA-PERTUSSIS [J].
HACKETT, M ;
GUO, L ;
SHABANOWITZ, J ;
HUNT, DF ;
HEWLETT, EL .
SCIENCE, 1994, 266 (5184) :433-435
[6]   BORDETELLA-PERTUSSIS AND BORDETELLA-PARAPERTUSSIS - 2 IMMUNOLOGICALLY DISTINCT SPECIES [J].
KHELEF, N ;
DANVE, B ;
QUENTINMILLET, MJ ;
GUISO, N .
INFECTION AND IMMUNITY, 1993, 61 (02) :486-490
[7]   BOTH ADENYLATE-CYCLASE AND HEMOLYTIC ACTIVITIES ARE REQUIRED BY BORDETELLA-PERTUSSIS TO INITIATE INFECTION [J].
KHELEF, N ;
SAKAMOTO, H ;
GUISO, N .
MICROBIAL PATHOGENESIS, 1992, 12 (03) :227-235
[8]   BORDETELLA-PERTUSSIS INDUCES APOPTOSIS IN MACROPHAGES - ROLE OF ADENYLATE CYCLASE-HEMOLYSIN [J].
KHELEF, N ;
ZYCHLINSKY, A ;
GUISO, N .
INFECTION AND IMMUNITY, 1993, 61 (10) :4064-4071
[9]  
ROGEL A, 1992, J BIOL CHEM, V267, P22599
[10]   REPEAT SEQUENCES IN THE BORDETELLA-PERTUSSIS ADENYLATE-CYCLASE TOXIN CAN BE RECOGNIZED AS ALTERNATIVE CARBOXY-PROXIMAL SECRETION SIGNALS BY THE ESCHERICHIA-COLI ALPHA-HEMOLYSIN TRANSLOCATOR [J].
SEBO, P ;
LADANT, D .
MOLECULAR MICROBIOLOGY, 1993, 9 (05) :999-1009
1