Gamma-lactams and related compounds as cholesterol absorption inhibitors: Homologs of the beta-lactam cholesterol absorption inhibitor SCH 48461

被引：24

作者：

Dugar, S

Kirkup, MP

Clader, JW

Lin, SI

Rizvi, R

Snow, ME

Davis, HR

McCombie, SW

机构：

[1] Schering Plough Research Institute, Kenilworth, NJ 07033

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 24期

关键词：

D O I：

10.1016/0960-894X(95)00516-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Our search for potent cholesterol absorption inhibitors led to the discovery of the p-lactam SCH 48461. Structure activity relationship studies prompted us to this study of gamma-lactams, ring homologs of beta-lactam SCH 48461, to determine their potential as cholesterol absorption inhibitors. The results indicate that the gamma-lactams have moderate cholesterol absorption inhibitory properties.

引用

页码：2947 / 2952

页数：6

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