PROTEIN MOLECULES AS COMPUTATIONAL ELEMENTS IN LIVING CELLS

被引：525
作者：
BRAY, D
机构：
[1] Department of Zoology, University of Cambridge, Cambridge
来源：
NATURE | 1995年 / 376卷 / 6538期
关键词：
D O I：
10.1038/376307a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Many proteins in living cells appear to have as their primary function the transfer and processing of information, rather than the chemical transformation of metabolic intermediates or the building of cellular structures. Such proteins are functionally linked through allosteric or other mechanisms into biochemical 'circuits' that perform a variety of simple computational tasks including amplification, integration and information storage.
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页码：307 / 312
页数：6
相关论文
共 40 条
[1]   SIGNAL INTEGRATION IN THE NERVOUS-SYSTEM - ADENYLATE CYCLASES AS MOLECULAR COINCIDENCE DETECTORS [J].
ANHOLT, RRH .
TRENDS IN NEUROSCIENCES, 1994, 17 (01) :37-41
[2]  
[Anonymous], 1995, BIOCHEMISTRY-US
[3]   SYNAPTIC PLASTICITY - A MOLECULAR SWITCH FOR MEMORY [J].
ANWYL, R .
CURRENT BIOLOGY, 1994, 4 (09) :854-856
[4]   COMPUTATIONAL FUNCTIONS IN BIOCHEMICAL REACTION NETWORKS [J].
ARKIN, A ;
ROSS, J .
BIOPHYSICAL JOURNAL, 1994, 67 (02) :560-578
[5]   TRANSIENT-RESPONSE TO CHEMOTACTIC STIMULI IN ESCHERICHIA-COLI [J].
BERG, HC ;
TEDESCO, PM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (08) :3235-3239
[6]   PROTEINS REGULATING RAS AND ITS RELATIVES [J].
BOGUSKI, MS ;
MCCORMICK, F .
NATURE, 1993, 366 (6456) :643-654
[7]   THE GTPASE SUPERFAMILY - A CONSERVED SWITCH FOR DIVERSE CELL FUNCTIONS [J].
BOURNE, HR ;
SANDERS, DA ;
MCCORMICK, F .
NATURE, 1990, 348 (6297) :125-132
[8]   INTRACELLULAR SIGNALING AS A PARALLEL DISTRIBUTED PROCESS [J].
BRAY, D .
JOURNAL OF THEORETICAL BIOLOGY, 1990, 143 (02) :215-231
[9]   COMPUTER-SIMULATED EVOLUTION OF A NETWORK OF CELL-SIGNALING MOLECULES [J].
BRAY, D ;
LAY, S .
BIOPHYSICAL JOURNAL, 1994, 66 (04) :972-977
[10]   COMPUTER-SIMULATION OF THE PHOSPHORYLATION CASCADE CONTROLLING BACTERIAL CHEMOTAXIS [J].
BRAY, D ;
BOURRET, RB ;
SIMON, MI .
MOLECULAR BIOLOGY OF THE CELL, 1993, 4 (05) :469-482
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