EXTENSION OF LIFE-SPAN BY OVEREXPRESSION OF SUPEROXIDE-DISMUTASE AND CATALASE IN DROSOPHILA-MELANOGASTER

被引：1209
作者：
ORR, WC
SOHAL, RS
机构：
[1] Department of Biological Sciences, Southern Methodist University, Dallas
来源：
SCIENCE | 1994年 / 263卷 / 5150期
关键词：
D O I：
10.1126/science.8108730
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The hypothesis that oxygen free radicals are causally involved in the aging process was tested by a study of the effects of simultaneous overexpression of copper-zinc superoxide dismutase and catalase. As compared to diploid controls, transgenic flies carrying three copies of each of these genes exhibited as much as a one-third extension of life-span, a longer mortality rate doubling time, a lower amount of protein oxidative damage, and a delayed loss in physical performance. Results provide direct support for the free radical hypothesis of aging.
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页码：1128 / 1130
页数：3
相关论文
共 26 条
[1]   RANKING POSSIBLE CARCINOGENIC HAZARDS [J].
AMES, BN ;
MAGAW, R ;
GOLD, LS .
SCIENCE, 1987, 236 (4799) :271-280
[2]  
[Anonymous], 1974, ESTIMATION CATALASE
[3]  
[Anonymous], MODERN BIOL THEORIES
[4]   HYDROPEROXIDE METABOLISM IN MAMMALIAN ORGANS [J].
CHANCE, B ;
SIES, H ;
BOVERIS, A .
PHYSIOLOGICAL REVIEWS, 1979, 59 (03) :527-605
[5]  
Finch C. E., 1990, SENESCENCE GENOME
[6]   BIOLOGY OF OXYGEN RADICALS [J].
FRIDOVICH, I .
SCIENCE, 1978, 201 (4359) :875-880
[7]   OXYGEN-TOXICITY, OXYGEN RADICALS, TRANSITION-METALS AND DISEASE [J].
HALLIWELL, B ;
GUTTERIDGE, JMC .
BIOCHEMICAL JOURNAL, 1984, 219 (01) :1-14
[8]   AGING - A THEORY BASED ON FREE-RADICAL AND RADIATION-CHEMISTRY [J].
HARMAN, D .
JOURNALS OF GERONTOLOGY, 1956, 11 (03) :298-300
[9]   THE AGING PROCESS [J].
HARMAN, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :7124-7128
[10]   TISSUE-SPECIFICITY OF DROSOPHILA P-ELEMENT TRANSPOSITION IS REGULATED AT THE LEVEL OF MESSENGER-RNA SPLICING [J].
LASKI, FA ;
RIO, DC ;
RUBIN, GM .
CELL, 1986, 44 (01) :7-19
123