Near Full-Length Genomic Characterization of Two Novel HIV Type 1 Second-Generation Recombinant Forms (CRF01_AE/CRF07_BC) from Guangxi, China

被引：0

作者：

Liu, Meiliang ^{[1
]}

Chen, Huanhuan ^{[2
]}

Li, Jianjun ^{[2
]}

Cai, Wenlong ^{[2
]}

Xie, Haomin ^{[2
]}

Lan, Guanghua ^{[2
]}

Zeng, Xiaoyun ^{[1
]}

机构：

[1] Guangxi Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Nanning, Guangxi, Peoples R China

[2] Guangxi Ctr Dis Control & Prevent, Guangxi Key Lab Major Infect Dis Prevent Control, Nanning, Peoples R China

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2023年 / 39卷 / 10期

关键词：

HIV-1; recombinant form; CRF01_AE/CRF07_BC; phenotypic tropism; Guangxi; IDENTIFICATION; EPIDEMIC; CRF01-AE;

D O I：

10.1089/aid.2023.0043

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CRF01_AE and CRF07_BC are the two predominant HIV-1 subtypes currently circulating in China. We identified here a novel CCR5-tropic HIV-1 second-generation recombinant form virus found in two individuals, (GX19017 and GX19032), which were isolated from two HIV-1-positive people in Guangxi, southwest China. Phylogenic analyses indicated that these two sequences were all composed of two well-established circulating recombinant forms (CRFs) CRF07_BC and CRF01_AE, with four recombinant breakpoints observed in the pol, vpu/env, and env gene regions, respectively. The recombinant CRF01_AE region was clustered with the previously described CRF01_AE subcluster 2 lineage, which was characterized by the susceptibility to phenotypic transfer. The genome structure is significantly different from other previously reported CRFs and unique recombination forms. The emergence of a series of novel recombinant strains is indicative of the burgeoning complexity of the HIV-1 epidemic among the sexually transmitted population. Meanwhile, it may furnish significant insights into the dynamics and intricacy of the HIV-1 epidemic in China.

引用

页码：567 / 574

页数：8

共 30 条

[21] Disparate impact on CD4 T cell count by two distinct HIV-1 phylogenetic clusters from the same Glade [J].

Song, Hongshuo ;

Ou, Weidong ;

Feng, Yi ;

Zhang, Junli ;

Li, Fan ;

Hu, Jing ;

Peng, Hong ;

Xing, Hui ;

Ma, Liying ;

Tan, Qiuxiang ;

Li, Dongliang ;

Wang, Lijuan ;

Wu, Beili ;

Shao, Yiming .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (01) :239-244

[22] Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome [J].

Song, Hongshuo ;

Pavlicek, Jeffrey W. ;

Cai, Fangping ;

Bhattacharya, Tanmoy ;

Li, Hui ;

Iyer, Shilpa S. ;

Bar, Katharine J. ;

Decker, Julie M. ;

Goonetilleke, Nilu ;

Liu, Michael Kp ;

Berg, Anna ;

Hora, Bhavna ;

Drinker, Mark S. ;

Eudailey, Josh ;

Pickeral, Joy ;

Moody, M. Anthony ;

Ferrari, Guido ;

McMichael, Andrew ;

Perelson, Alan S. ;

Shaw, George M. ;

Hahn, Beatrice H. ;

Haynes, Barton F. ;

Gao, Feng .

RETROVIROLOGY, 2012, 9

[23] Replication and drug resistant mutation of HIV-1 subtype B' (Thailand B) variants isolated from HAART treatment individuals in China [J].

Sun, Jianping ;

Ma, Liying ;

Yu, Xiaoling ;

Huang, Yang ;

Yuan, Lin ;

Shao, Yiming .

VIROLOGY JOURNAL, 2009, 6

[24] Quantitative evaluation of HIV-1 coreceptor use in the GHOST(3) cell assay [J].

Vödrös, D ;

Tscherning-Casper, C ;

Navea, L ;

Schols, D ;

De Clercq, E ;

Fenyö, EM .

VIROLOGY, 2001, 291 (01) :1-11

[25] The impact of SARS-CoV-2 infection in children with rheumatic/autoinflammatory diseases on immunosuppressive treatment: a single centre experience [J].

Maritsi, D. N. ;

Krepis, P. ;

Vartzelis, G. ;

Syggelou, A. ;

Tsolia, M. N. .

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2023, 41 (09) :S4-S5

[26]

Wang C, 2018, AIDS RES HUM RETROV, V34, P635, DOI [10.1089/aid.2018.0070, 10.1089/AID.2018.0070]

[27] Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960 [J].

Worobey, Michael ;

Gemmel, Marlea ;

Teuwen, Dirk E. ;

Haselkorn, Tamara ;

Kunstman, Kevin ;

Bunce, Michael ;

Muyembe, Jean-Jacques ;

Kabongo, Jean-Marie M. ;

Kalengayi, Raphael M. ;

Van Marck, Eric ;

Gilbert, M. Thomas P. ;

Wolinsky, Steven M. .

NATURE, 2008, 455 (7213) :661-U57

[28] A highly virulent variant of HIV-1 circulating in the Netherlands [J].

Wymant, Chris ;

Bezemer, Daniela ;

Blanquart, Francois ;

Ferretti, Luca ;

Gall, Astrid ;

Hall, Matthew ;

Golubchik, Tanya ;

Bakker, Margreet ;

Ong, Swee Hoe ;

Zhao, Lele ;

Bonsall, David ;

de Cesare, Mariateresa ;

MacIntyre-Cockett, George ;

Abeler-Doerner, Lucie ;

Albert, Jan ;

Bannert, Norbert ;

Fellay, Jacques ;

Grabowski, M. Kate ;

Gunsenheimer-Bartmeyer, Barbara ;

Gunthard, Huldrych F. ;

Kivela, Pia ;

Kouyos, Roger D. ;

Laeyendecker, Oliver ;

Meyer, Laurence ;

Porter, Kholoud ;

Ristola, Matti ;

van Sighem, Ard ;

Ben Berkhout ;

Kellam, Paul ;

Cornelissen, Marion ;

Reiss, Peter ;

Fraser, Christophe .

SCIENCE, 2022, 375 (6580) :540-+

[29] Substitution of gp120 C4 region compensates for V3 loss-of-fitness mutations in HIV-1 CRF01_AE co-receptor switching [J].

Yu, Yueyang ;

Feng, Yi ;

Zhou, Zehua ;

Li, Kang ;

Hu, Xiaoyan ;

Liao, Lingjie ;

Xing, Hui ;

Shao, Yimig .

EMERGING MICROBES & INFECTIONS, 2023, 12 (01)

[30] Identification of Two Similar Novel HIV-1 Recombinant Forms (CRF01_AE/CRF07_BC) among Intravenous Drug Users in Guangxi, China [J].

Zhang, Fei ;

Yang, Yao ;

Liang, Bingyu ;

Yang, Yuan ;

Wei, Qiuyu ;

Pan, Peijiang ;

Ye, Li ;

Liang, Hao .

INTERVIROLOGY, 2022, 65 (01) :58-66

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