Near Full-Length Genomic Characterization of Two Novel HIV Type 1 Second-Generation Recombinant Forms (CRF01_AE/CRF07_BC) from Guangxi, China

被引：0

作者：

Liu, Meiliang ^{[1
]}

Chen, Huanhuan ^{[2
]}

Li, Jianjun ^{[2
]}

Cai, Wenlong ^{[2
]}

Xie, Haomin ^{[2
]}

Lan, Guanghua ^{[2
]}

Zeng, Xiaoyun ^{[1
]}

机构：

[1] Guangxi Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Nanning, Guangxi, Peoples R China

[2] Guangxi Ctr Dis Control & Prevent, Guangxi Key Lab Major Infect Dis Prevent Control, Nanning, Peoples R China

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2023年 / 39卷 / 10期

关键词：

HIV-1; recombinant form; CRF01_AE/CRF07_BC; phenotypic tropism; Guangxi; IDENTIFICATION; EPIDEMIC; CRF01-AE;

D O I：

10.1089/aid.2023.0043

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CRF01_AE and CRF07_BC are the two predominant HIV-1 subtypes currently circulating in China. We identified here a novel CCR5-tropic HIV-1 second-generation recombinant form virus found in two individuals, (GX19017 and GX19032), which were isolated from two HIV-1-positive people in Guangxi, southwest China. Phylogenic analyses indicated that these two sequences were all composed of two well-established circulating recombinant forms (CRFs) CRF07_BC and CRF01_AE, with four recombinant breakpoints observed in the pol, vpu/env, and env gene regions, respectively. The recombinant CRF01_AE region was clustered with the previously described CRF01_AE subcluster 2 lineage, which was characterized by the susceptibility to phenotypic transfer. The genome structure is significantly different from other previously reported CRFs and unique recombination forms. The emergence of a series of novel recombinant strains is indicative of the burgeoning complexity of the HIV-1 epidemic among the sexually transmitted population. Meanwhile, it may furnish significant insights into the dynamics and intricacy of the HIV-1 epidemic in China.

引用

页码：567 / 574

页数：8

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