ALL-D-MAGAININ - CHIRALITY, ANTIMICROBIAL ACTIVITY AND PROTEOLYTIC RESISTANCE

被引：306
作者：
BESSALLE, R
KAPITKOVSKY, A
GOREA, A
SHALIT, I
FRIDKIN, M
机构：
[1] WEIZMANN INST SCI,DEPT ORGAN CHEM,IL-76100 REHOVOT,ISRAEL
[2] TEL AVIV SOURASKY MED CTR,INFECT DIS UNIT,CLIN MICROBIOL RES LAB,TEL AVIV,ISRAEL
来源：
FEBS LETTERS | 1990年 / 274卷 / 1-2期
关键词：
All-D-magainin; Proteolytic stability: Clinical potential; Surface-activity;
D O I：
10.1016/0014-5793(90)81351-N
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
All-D-magainin-2 was synthesized to corroborate experimentally the notion that the biological function of a surface-active peptide stems primarily from its unique amphiphilic α -helical structure. Indeed, the peptide exhibited antibacterial potency nearly identical to that of the all-L-enantiomer. Being highly resistant to proteolysis and non-hemolytic all-D-magainin might have considerable therapeutic importance. © 1990.
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页码：151 / 155
页数：5
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