ANTAGONISM OF 5-HT3 RECEPTORS ATTENUATES THE EFFECTS OF ETHANOL ON EXTRACELLULAR DOPAMINE

被引：129

作者：

WOZNIAK, KM ^{[1
]}

PERT, A ^{[1
]}

LINNOILA, M ^{[1
]}

机构：

[1] NIMH,BIOL PSYCHIAT BRANCH,BETHESDA,MD 20892

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 187卷 / 02期

关键词：

5-HT[!sub]3[!/sub] receptors; Dopamine; Ethanol; Microdialysis; Nucleus accumbens; Striatum;

D O I：

10.1016/0014-2999(90)90015-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of a 5-HT3 antagonist, ICS 205-930, on ethanol-induced changes in extracellular dopamine, was investigated with in vivo microdialysis. Pretreatment of rats with ICS 205-930 effectively attenuated the subsequent increases in dopamine, in both the nucleus accumbens and corpus striatum. This suggests that 5-HT may be involved in the effects of ethanol on dopaminergic systems. © 1990.

引用

页码：287 / 289

页数：3

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