INHIBITION OF PLATELET-AGGREGATION BY SHIKONIN DERIVATIVES ISOLATED FROM ARNEBIA-EUCHROMA

被引：42

作者：

CHANG, YS

KUO, SC

WENG, SH

JAN, SC

KO, FN

TENG, CM

机构：

[1] CHINA MED COLL,GRAD INST PHARMACEUT CHEM,91 HSUEH SHIH RD,TAICHUNG,TAIWAN

[2] NATL RES INST CHINESE MED,TAIPEI,TAIWAN

[3] NATL TAIWAN UNIV,COLL MED,INST PHARMACOL,TAIPEI,TAIWAN

来源：

PLANTA MEDICA | 1993年 / 59卷 / 05期

关键词：

PLATELET AGGREGATION; VASORELAXATION; ARNEBIA-EUCHROMA; SHIKONIN; ACETYLSHIKONIN; BETA; BETA-DIMETHYLACRYLSHIKONIN; TERACRYLSHIKONIN;

D O I：

10.1055/s-2006-959718

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four antiplatelet components were isolated from Arnebia euchroma. They inhibited the aggregation of washed rabbit platelets caused by collagen, arachidonic acid, platelet-activating factor, ADP, or thrombin. The potency of inhibiting collagen-induced platelet aggregation is in the following order: acetylshikonin (IC50 = 2.1 muM), teracrylshikonin (2.8 muM), beta,beta-dimethylacrylshikonin (4.2 muM), and shikonin (10.7 muM). In rat aorta, acetylshikonin and shikonin inhibited high potassium and norepinephrine-induced contractions, while beta,beta-dimethylacrylshikonin and teracrylshikonin potentiated the phasic contraction caused by nor epinephrine.

引用

页码：401 / 404

页数：4

共 24 条

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