SYNTHESIS AND CHARACTERIZATION OF A SERIES OF HYDROPHOBIC ANTITUMOR AMINE PLATINUM(II) CARBOXYLATES

被引：5
作者：
KHOKHAR, AR
XU, QY
机构：
[1] Department of Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030
来源：
JOURNAL OF COORDINATION CHEMISTRY | 1990年 / 22卷 / 01期
关键词：
PLATINUM; AMINE; CARBOXYLATE; HYDROPHOBICITY; SYNTHESIS;
D O I：
10.1080/00958979009408207
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
As part of a systematic study, a series of hydrophobic amine platinum(II) carboxylate complexes has been prepared as potential antitumor agents in a liposomal-entrapped form. These complexes have been characterized by elemental analysis, IR, 13C and 195Pt NMR spectroscopic techniques. Effect of ligand donors on NMR chemical shift is briefly discussed. © 1990, Taylor & Francis Group, LLC. All rights reserved.
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页码：53 / 58
页数：6
相关论文
共 17 条
[1]   N-15 AND PT-195 NMR-SPECTRA OF PLATINUM AMMINE COMPLEXES - TRANSINFLUENCE AND CIS-INFLUENCE SERIES BASED ON PT-195-N-15 COUPLING-CONSTANTS AND N-15 CHEMICAL-SHIFTS [J].
APPLETON, TG ;
HALL, JR ;
RALPH, SF .
INORGANIC CHEMISTRY, 1985, 24 (26) :4685-4693
[2]   RELATIONSHIPS BETWEEN THE CARBON-OXYGEN STRETCHING FREQUENCIES OF CARBOXYLATO COMPLEXES AND THE TYPE OF CARBOXYLATE COORDINATION [J].
DEACON, GB ;
PHILLIPS, RJ .
COORDINATION CHEMISTRY REVIEWS, 1980, 33 (03) :227-250
[3]  
Dhara S. C., 1970, INDIAN J CHEM, P193
[4]  
FREISE J, 1982, ARCH INT PHARMACOD T, V258, P180
[5]  
KHOKHAR AR, 1989, CANCER CHEMOTH PHARM, V23, P219
[6]   SYNTHESIS AND CHARACTERIZATION OF A SERIES OF PLATINUM(II) AND PALLADIUM(II) COMPLEXES CONTAINING THE BIDENTATE LIGAND MESO-1,2-DIPHENYLETHYLENEDIAMINE OR MESO-1,2-BIS(4-CHLOROPHENYL) ETHYLENEDIAMINE [J].
KHOKHAR, AR ;
LUMETTA, GJ .
JOURNAL OF COORDINATION CHEMISTRY, 1989, 19 (04) :321-330
[7]  
KHOKHAR AR, 1988, ANTI-CANCER DRUG DES, V3, P177
[8]  
KHOKHAR AR, 1988, J COORD CHEM, V18, P29
[9]  
Mayhew E., 1983, LIPOSOMES, P289
[10]  
Nakamoto K, 1978, INFRARED RAMAN SPECT, P232
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