THE XENOPUS-B1 FACTOR IS CLOSELY RELATED TO THE MAMMALIAN ACTIVATOR USF AND IS IMPLICATED IN THE DEVELOPMENTAL REGULATION OF TFIIIA GENE-EXPRESSION

被引：57

作者：

KAULEN, H ^{[1
]}

POGNONEC, P ^{[1
]}

GREGOR, PD ^{[1
]}

ROEDER, RG ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,BIOCHEM & MOLEC BIOL LAB,1230 YORK AVE,NEW YORK,NY 10021

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1991年 / 11卷 / 01期

关键词：

D O I：

10.1128/MCB.11.1.412

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Xenopus laevis TFIIIA promoter contains a motif that has been implicated in promoter activation in late-stage oocytes and contains the sequence (-269) CACGTG (-264). A cDNA encoding a protein (B1) that binds to this element has been cloned from X. laevis and Xenopus borealis ovarian cDNA libraries. We show that this protein is a member of the helix-loop-helix family of regulatory proteins and contains 80% sequence identity with the human adenovirus major late transcription factor (MLTF or USF). A survey of B1 protein expression during oogenesis and embryogenesis revealed both oocyte-specific and somatic cell-specific B1 protein-DNA complexes. Immunological data, RNA blot analysis, and proteolytic clipping band shift assays indicated that these complexes most likely represent altered forms of a single B1 polypeptide. Implications for TFIIIA gene regulation during development are discussed.

引用

页码：412 / 424

页数：13

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