IRON AND BACTERIAL VIRULENCE - A BRIEF OVERVIEW

被引：71
作者：
GRIFFITHS, E
机构：
[1] National Institute for Biological Standards and Control, Hertfordshire, South Mimms, Potters Bar
来源：
BIOLOGY OF METALS | 1991年 / 4卷 / 01期
关键词：
IRON AVAILABILITY; MICROBIAL PATHOGENICITY; IRON-UPTAKE SYSTEM; HEME;
D O I：
10.1007/BF01135551
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Iron is now recognized as playing a vital role in infection. Not only does its restricted availability in tissue fluids present microbial pathogens with the problem of acquiring sufficient for multiplication in vivo, but it also constitutes a major environmental signal which co-ordinately regulates the expression of a number of virulence and metabolic genes. Progress in understanding the strategies used by pathogens for acquiring iron in vivo, and their responses to iron restriction, is providing a fresh insight into microbial pathogenicity. © 1991 Springer-Verlag.
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页码：7 / 13
页数：7
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