TETRACYCLINES AND HOST DEFENSE-MECHANISMS - INTERFERENCE WITH LEUKOCYTE CHEMOTAXIS

被引：46
作者：
BELSHEIM, J
GNARPE, H
PERSSON, S
机构：
[1] GAVLE HOSP,DEPT CLIN BACTERIOL,S-80007 GAVLE,SWEDEN
[2] GAVLE HOSP,DEPT SURG,GAVLE,SWEDEN
来源：
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 1979年 / 11卷 / 02期
关键词：
D O I：
10.3109/inf.1979.11.issue-2.08
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The influence of 2 tetracycline preparations, lymecycline and doxycycline, on leukocyte chemotaxis, was investigated in vitro and in vivo. Doxycycline in high concentrations caused a severe depression of both spontaneous and induced migration, an effect which was more pronounced than that caused by similar concentration of lymecycline. Corresponding results were obtained both in experiments on healthy volunteers given recommended dosages of the antibiotics, and in patients treated with doxycycline for postoperative infections. © 1979, Informa UK Ltd. All rights reserved.
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页码：141 / 145
页数：5
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