STRUCTURE ELUCIDATION OF 2 DIPHENYLHYDANTOIN DERIVATIVES VIA H-1 AND C-13 NMR-SPECTROSCOPY

被引：3

作者：

CIECHANOWICZRUTKOWSKA, M

RAGONA, L

GRECO, F

ZETTA, L

PEGNA, M

机构：

[1] CNR,IST CHIM MACROMOLEC,NMR LAB,I-20133 MILAN,ITALY

[2] JAGIELLONIAN UNIV,REG PHYSICOCHEM ANAL & STRUCT RES LAB,PL-30060 KRAKOW,POLAND

[3] CNR,IST CHIM MACROMOLEC,NMR LAB,TECHNOBIOLCHIP,I-20133 MILAN,ITALY

[4] CNR,IST CHIM MACROMOLEC,NMR LAB,ITALFARMACO,I-20133 MILAN,ITALY

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 1995年 / 33卷 / 07期

关键词：

H-1; NMR; AMPHIPATHIC STRUCTURE; DIPHENYLHYDANTOIN DERIVATIVES; ANTICONVULSANTS; ANTIDEPRESSANT;

D O I：

10.1002/mrc.1260330716

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The solution conformations of 1-benzyl-5,5-diphenyl-2,4-dioxo-3-imidazolidineacetic acid (AC) and 3-(2,4-dichlorobenzyl)-5,5-diphenyl-2,4-dioxo-1-imidazolidine acetic acid (AD) were studied by proton and carbon NMR spectroscopy. The two drugs have different pharmacological activities, AC having anticonvulsant and AD having antidepressant but no anticonvulsant properties. The relative orientations of the hydantoin ring substituents were investigated and are discussed in terms of amphipathic distribution of polar and apolar domains.

引用

页码：586 / 591

页数：6

共 7 条

[1] BLOCKADE OF CARDIAC SODIUM-CHANNELS BY AMITRIPTYLINE AND DIPHENYLHYDANTOIN - EVIDENCE FOR 2 USE-DEPENDENT BINDING-SITES [J].