INDUCTION OF AROMATASE IN STROMAL-VASCULAR CELLS FROM HUMAN BREAST ADIPOSE-TISSUE DEPENDS ON CORTISOL AND GROWTH-FACTORS

被引：18
作者：
SCHMIDT, M [1 ]
LOFFLER, G [1 ]
机构：
[1] UNIV REGENSBURG, INST BIOCHEM GENET & MICROBIOL, D-93040 REGENSBURG, GERMANY
来源：
FEBS LETTERS | 1994年 / 341卷 / 2-3期
关键词：
AROMATASE; CORTISOL; PDGF; BFGF; BREAST ADIPOSE TISSUE (HUMAN);
D O I：
10.1016/0014-5793(94)80452-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The regulation of aromatase (estrogen synthase) activity of cultured stromal vascular cells from human breast adipose tissue by cortisol, db-cAMP and growth factors was studied in a serum-free culture system. While PDGF-BB alone inhibited the effect of db-cAMP on aromatase induction, it stimulated aromatase activity in the presence of cortisol with or without db-cAMP. In the presence of 1 muM insulin consistently higher aromatase activities were found as compared to 1 nM insulin. In contrast to PDGF-BB, bFGF led to an increase of aromatase activity only in the presence of both cortisol and db-cAMP.
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页码：177 / 181
页数：5
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