TMB-8(8-(N,N-DIETHYLAMINO)OCTYL-3,4,5-TRIMETHOXYBENZOATE) INHIBITS THE ATP-SENSITIVE K+ CHANNEL

被引：16

作者：

SZEWCZYK, A ^{[1
]}

DEWEILLE, JR ^{[1
]}

LAZDUNSKI, M ^{[1
]}

机构：

[1] INST PHARMACOL MOLEC & CELLULAIRE,660 ROUTE LUCIOLES,F-06560 VALBONNE,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 226卷 / 02期

关键词：

TMB-8(8-(N,N-DIETHYLAMINO)OCTYL-3,4,5-TRIMETHOXYBENZOATE); ATP-SENSITIVE POTASSIUM CHANNEL; BETA-CELLS;

D O I：

10.1016/0922-4106(92)90180-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Whole-cell current clamp, single-channel recordings and Rb-86+ flux techniques have been used to show that 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate (TMB-8) inhibits ATP-sensitive K+ channels in HIT-T15 beta-cells. TMB-8 inhibition is observed when K(ATP) channels are activated by ATP depletion or by the K+ channel opener, diazoxide.

引用

页码：175 / 177

页数：3

共 50 条

[41] PHORBOL NYRISTATE ACETATE-INDUCED RELEASE OF GRANULE ENZYMES FROM HUMAN-NEUTROPHILS - INHIBITION BY THE CALCIUM ANTAGONIST, 8-(N,N-DIETHYLAMINO)-OCTYL 3,4,5-TRIMETHOXYBENZOATE HYDROCHLORIDE
SMITH, RJ
IDEN, SS
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1979, 91 (01) : 263 - 271
[42] EFFECTS OF 5-(N,N-DIETHYLAMINO)-NORMAL-PENTYL-3,4,5-TRIMETHOXYBENZOATE HYDROCHLORIDE (TMB-5) ON CARDIOVASCULAR SYSTEMS
CHIOU, GCY
MCLAUGHLIN, MA
EUROPEAN JOURNAL OF PHARMACOLOGY, 1982, 81 (04) : 587 - 594
[43] 8-(N,N-Diethylamino)-n-octyl-3,4,5-trimethoxybenzoate reduced (Ca2+)i elevation induced by histamine,serotonin,and glutamate in cultured calf basilar artery smooth muscle cells
王斌
张孝清
刘天培
肖继皋
ActaPharmacologicaSinica, 1998, (03) : 56 - 58
[44] 8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate reduced [Ca2+]i elevation induced by histamine, serotonin, and glutamate in cultured calf basilar artery smooth muscle cells
Wang, B
Zhang, XQ
Liu, TP
Xiao, JG
ACTA PHARMACOLOGICA SINICA, 1998, 19 (03): : 251 - 253
[45] NICOTINE ANTAGONISTS - STUDIES ON OMEGA-(N,N-DIETHYLAMINO)-NORMAL-BUTYL 3,4,5-TRIMETHOXYBENZOATE (TMB-4) AS AN ANTAGONIST OF NICOTINE
RAMASAST.BV
ROBINSON, CP
CHIOU, CY
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1974, 29 (01) : 98 - 98
[46] [8-(diethylamino)octyl-3,4,5-trimethoxybenzoate, HCl], the inhibitor of intracellular calcium mobilization, blocked mitogen-induced T cell proliferation by interfering with the sustained phase of protein kinase C activation
Kumar, S
Chakrabarti, R
JOURNAL OF CELLULAR BIOCHEMISTRY, 2000, 76 (04) : 539 - 547
[47] EFFECTS OF CALCIUM ANTAGONIST, 6-(N,N-DIETHYLAMINO)HEXYL-3,4,5-TRIMETHOXYBENZOATE, ON DIGITALIS-INDUCED ARRHYTHMIAS AND CARDIAC CONTRACTIONS
CHIOU, CY
MALAGODI, MH
SASTRY, BVR
POSNER, P
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1976, 198 (02): : 444 - 449
[48] EFFECTS OF 8-(N,N-DIETHYLAMINE)-OCTYL 3,4,5-TRIMETHOXY-BENZOATE,HC1 (TMB-8) ON PLATELET-RELEASE REACTION AND LOSS OF PLATELET CONSTITUENTS
MURER, EH
SIOJO, E
JAMES, P
NIEWIAROWSKI, S
FEDERATION PROCEEDINGS, 1980, 39 (06) : 2101 - 2101
[49] MODULATION OF HUMAN NEUTROPHIL SUPEROXIDE ANION GENERATION BY THE CALCIUM-ANTAGONIST 8-(N,N-DIETHYLAMINO)-OCTYL-(3,4,5-TRIMETHOXY) BENZOATE HYDROCHLORIDE
SMITH, RJ
IDEN, SS
JOURNAL OF THE RETICULOENDOTHELIAL SOCIETY, 1981, 29 (03): : 215 - 225
[50] INFLUENCE OF 6-(N,N-DIETHYLAMINO)HEXYL 3,4,5-TRIMETHOXYBENZOATE ON THE RESPONSIVENESS OF AORTAE TO NOREPINEPHRINE AND CALCIUM MOVEMENTS IN MICROSOMES FROM SPONTANEOUSLY HYPERTENSIVE AND NORMOTENSIVE RATS
CHATURVEDI, AK
LANDON, EJ
SASTRY, BVR
PHARMACOLOGY, 1978, 17 (06) : 315 - 322

← 1 2 3 4 5 →