TMB-8(8-(N,N-DIETHYLAMINO)OCTYL-3,4,5-TRIMETHOXYBENZOATE) INHIBITS THE ATP-SENSITIVE K+ CHANNEL

被引：16

作者：

SZEWCZYK, A ^{[1
]}

DEWEILLE, JR ^{[1
]}

LAZDUNSKI, M ^{[1
]}

机构：

[1] INST PHARMACOL MOLEC & CELLULAIRE,660 ROUTE LUCIOLES,F-06560 VALBONNE,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 226卷 / 02期

关键词：

TMB-8(8-(N,N-DIETHYLAMINO)OCTYL-3,4,5-TRIMETHOXYBENZOATE); ATP-SENSITIVE POTASSIUM CHANNEL; BETA-CELLS;

D O I：

10.1016/0922-4106(92)90180-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Whole-cell current clamp, single-channel recordings and Rb-86+ flux techniques have been used to show that 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate (TMB-8) inhibits ATP-sensitive K+ channels in HIT-T15 beta-cells. TMB-8 inhibition is observed when K(ATP) channels are activated by ATP depletion or by the K+ channel opener, diazoxide.

引用

页码：175 / 177

页数：3

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