POLY(ADP-RIBOSE) POLYMERASE;
STANDARDIZATION;
DNA;
OCTANUCLEOTIDE;
DNA STRAND BREAK;
D O I:
10.1139/o91-086
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
In this work, we examined the activation of poly(ADP-ribose) polymerase by various types of DNA. We have found that the best activator for poly(ADP-ribose) polymerase is an octanucleotide. However, the use of a defined activated DNA is also suitable.
机构:
Ecole Super Biotechnol Strasbourg, Dept Integrite Genom, CNRS, Lab Convent Avec Commissariat Energie Atom, Illkirch Graffenstaden, FranceEcole Super Biotechnol Strasbourg, Dept Integrite Genom, CNRS, Lab Convent Avec Commissariat Energie Atom, Illkirch Graffenstaden, France
Dantzer, Francoise
Ame, Jean-Christophe
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机构:Ecole Super Biotechnol Strasbourg, Dept Integrite Genom, CNRS, Lab Convent Avec Commissariat Energie Atom, Illkirch Graffenstaden, France
Ame, Jean-Christophe
Schreiber, Valerie
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机构:Ecole Super Biotechnol Strasbourg, Dept Integrite Genom, CNRS, Lab Convent Avec Commissariat Energie Atom, Illkirch Graffenstaden, France
Schreiber, Valerie
Nakamura, Jun
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机构:Ecole Super Biotechnol Strasbourg, Dept Integrite Genom, CNRS, Lab Convent Avec Commissariat Energie Atom, Illkirch Graffenstaden, France
Nakamura, Jun
Menissier-de Murcia, Josiane
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机构:Ecole Super Biotechnol Strasbourg, Dept Integrite Genom, CNRS, Lab Convent Avec Commissariat Energie Atom, Illkirch Graffenstaden, France
Menissier-de Murcia, Josiane
de Murcia, Gilbert
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机构:Ecole Super Biotechnol Strasbourg, Dept Integrite Genom, CNRS, Lab Convent Avec Commissariat Energie Atom, Illkirch Graffenstaden, France
机构:
Univ Debrecen, Dept Med Chem, H-4032 Debrecen, Hungary
MTA DE Lendulet Lab Cellular Metab Res Grp, H-4032 Debrecen, Hungary
Univ Debrecen, Res Ctr Mol Med, H-4032 Debrecen, HungaryUniv Debrecen, Dept Med Chem, H-4032 Debrecen, Hungary
Bai, Peter
Csoka, Balazs
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机构:
Rutgers State Univ, Dept Surg, New Jersey Med Sch, Newark, NJ 07103 USA
Rutgers State Univ, Ctr Immun & Inflammat, New Jersey Med Sch, Newark, NJ 07103 USAUniv Debrecen, Dept Med Chem, H-4032 Debrecen, Hungary