ANALYSIS OF THE ACTIVATION OF POLY(ADP-RIBOSE) POLYMERASE BY VARIOUS TYPES OF DNA

被引:7
|
作者
HENGARTNER, C
LAGUEUX, J
POIRIER, GG
机构
[1] CHU LAVAL,RES CTR,MOLEC ENDOCRINOL LAB,POLY ADP RIBOSE METABOLISM GRP,2705 LAURIER BLVD,QUEBEC CITY G1V 4G2,QUEBEC,CANADA
[2] UNIV LAVAL,QUEBEC CITY G1V 4G2,QUEBEC,CANADA
关键词
POLY(ADP-RIBOSE) POLYMERASE; STANDARDIZATION; DNA; OCTANUCLEOTIDE; DNA STRAND BREAK;
D O I
10.1139/o91-086
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this work, we examined the activation of poly(ADP-ribose) polymerase by various types of DNA. We have found that the best activator for poly(ADP-ribose) polymerase is an octanucleotide. However, the use of a defined activated DNA is also suitable.
引用
收藏
页码:577 / 580
页数:4
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