ISOLATION AND SYNTHESIS OF ESPINTANOL, NEW ANTIPARASITIC MONOTERPENE

被引：64

作者：

HOCQUEMILLER, R ^{[1
]}

CORTES, D ^{[1
]}

ARANGO, GJ ^{[1
]}

MYINT, SH ^{[1
]}

CAVE, A ^{[1
]}

ANGELO, A ^{[1
]}

MUNOZ, V ^{[1
]}

FOURNET, A ^{[1
]}

机构：

[1] ORSTOM,IBBA,PHARMACOGNOSIE LAB,LA PAZ,BOLIVIA

来源：

JOURNAL OF NATURAL PRODUCTS | 1991年 / 54卷 / 02期

关键词：

D O I：

10.1021/np50074a015

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The in vitro leishmanicidal and trypanocidal activities of a petroleum ether extract of Oxandra espintana have been investigated. Four aromatic monoterpenes were isolated, of which two are novel: espintanol [3a], responsible for the antiparasite activity, and O-methylespintanol [4]. Espintanol was tested in vitro on 20 strains of Trypanosoma cruzi and 12 strains of Leishmania spp. Its structure was determined by spectroscopic methods and confirmed by its preparation starting from carvacrol.

引用

页码：445 / 452

页数：8

共 12 条

[1] ALKALOIDS OF THE ANNONACAEE .74. 3 BIS-DEHYDROAPORPHINES FROM OXANDRA CF MAJOR [J].