STEREOSELECTIVE SYNTHESIS OF NOVEL ANALOGS OF 2'DEOXYNUCLEOSIDES AND 2',3'-DIDEOXYNUCLEOSIDES WITH POTENTIAL ANTIVIRAL ACTIVITY

被引：27
作者：
CICERO, DO
NEUNER, PJS
FRANZESE, O
DONOFRIO, C
IRIBARREN, AM
机构：
[1] IST RIC BIOL MOLEC P ANGELETTI,I-00040 ROME,ITALY
[2] UNIV ROMA TOR VERGATA,DEPT EXPTL MED & BIOCHEM SCI,I-00173 ROME,ITALY
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 07期
关键词：
D O I：
10.1016/S0960-894X(01)80252-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The stereoselective synthesis of new 2'-deoxy- and 2',3'-dideoxy-2'-C-alkylnucleosides with potential antiviral activity is presented. The compounds here described were tested for their antiproliferative property against human tumor cell lines and none showed any significant antitumor activity.
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页码：861 / 866
页数：6
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