CANCER INCIDENCE IN A POPULATION ACCIDENTALLY EXPOSED TO 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN

被引：218

作者：

BERTAZZI, PA

PESATORI, AC

CONSONNI, D

TIRONI, A

LANDI, MT

ZOCCHETTI, C

机构：

[1] Institute of Occupational Health, School of Medicine, University of Milan, Milan

[2] EPOCA Research Center on Occupational, Clinical and Environmental Epidemiology, University of Milan, Milan

[3] Istituti Clinici di Perfezionamento, Clinica del Lavoro L. Devoto, Milan

来源：

EPIDEMIOLOGY | 1993年 / 4卷 / 05期

关键词：

DIOXINS; DISASTERS; ENVIRONMENTAL CARCINOGENS; ENVIRONMENTAL HEALTH; EPIDEMIOLOGIC METHODS; HORMONE-DEPENDENT NEOPLASMS; SOFT TISSUE NEOPLASMS;

D O I：

10.1097/00001648-199309000-00004

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In 1976, an accident in a plant near Seveso, Italy, exposed the local population to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Persons residing in three zones of decreasing TCDD contamination (A, B, and R) and a reference population were followed up for cancer occurrence in 1977-1986. The most exposed subgroup (A) was small, and only 14 cancer cases were observed. In zone B, hepatobiliary cancer was elevated, especially for those living in the area for >5 years [relative risk (RR) = 2.8; 95% confidence interval (CI) = 1.2-6.3]. Men exhibited an increase in hematologic neoplasms, most notably lymphoreticulosarcoma (RR = 5.7; 95% CI = 1.7-19.0). Women experienced an increased incidence of multiple myeloma (RR = 5.3; 95% CI = 1.2-22.6) and myeloid leukemia (RR = 3.7; 95% CI = 0.9-15.7). In zone R, the incidence of soft tissue tumors and non-Hodgkin's lymphomas was elevated, particularly among persons living in the area for >5 years (RR = 3.5; 95% CI = 1.2-10.4 for sarcomas, and RR = 2.0; 95% CI = 1.2-3.6 for non-Hodgkin's lymphomas). Breast cancer among females was below expectations in the most contaminated zones, and a clear deficit for endometrial cancer was observed in zones B and R.

引用

页码：398 / 406

页数：9

共 70 条

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