CANCER INCIDENCE IN A POPULATION ACCIDENTALLY EXPOSED TO 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN

被引：218

作者：

BERTAZZI, PA

PESATORI, AC

CONSONNI, D

TIRONI, A

LANDI, MT

ZOCCHETTI, C

机构：

[1] Institute of Occupational Health, School of Medicine, University of Milan, Milan

[2] EPOCA Research Center on Occupational, Clinical and Environmental Epidemiology, University of Milan, Milan

[3] Istituti Clinici di Perfezionamento, Clinica del Lavoro L. Devoto, Milan

来源：

EPIDEMIOLOGY | 1993年 / 4卷 / 05期

关键词：

DIOXINS; DISASTERS; ENVIRONMENTAL CARCINOGENS; ENVIRONMENTAL HEALTH; EPIDEMIOLOGIC METHODS; HORMONE-DEPENDENT NEOPLASMS; SOFT TISSUE NEOPLASMS;

D O I：

10.1097/00001648-199309000-00004

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In 1976, an accident in a plant near Seveso, Italy, exposed the local population to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Persons residing in three zones of decreasing TCDD contamination (A, B, and R) and a reference population were followed up for cancer occurrence in 1977-1986. The most exposed subgroup (A) was small, and only 14 cancer cases were observed. In zone B, hepatobiliary cancer was elevated, especially for those living in the area for >5 years [relative risk (RR) = 2.8; 95% confidence interval (CI) = 1.2-6.3]. Men exhibited an increase in hematologic neoplasms, most notably lymphoreticulosarcoma (RR = 5.7; 95% CI = 1.7-19.0). Women experienced an increased incidence of multiple myeloma (RR = 5.3; 95% CI = 1.2-22.6) and myeloid leukemia (RR = 3.7; 95% CI = 0.9-15.7). In zone R, the incidence of soft tissue tumors and non-Hodgkin's lymphomas was elevated, particularly among persons living in the area for >5 years (RR = 3.5; 95% CI = 1.2-10.4 for sarcomas, and RR = 2.0; 95% CI = 1.2-3.6 for non-Hodgkin's lymphomas). Breast cancer among females was below expectations in the most contaminated zones, and a clear deficit for endometrial cancer was observed in zones B and R.

引用

页码：398 / 406

页数：9

共 70 条

[1]

Polychlorinated Dibenzo-para-Dioxins and Dibenzofurans (Environmental Health Criteria 88), pp. 39-60, (1989)

[2]

Huff J.E., Salmon A.G., Hooper N.K., Zeise L., Long-term carcinogenesis studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin and hexachlorodibenzo-p-dioxins, Cell Biol Toxicol, 7, pp. 67-94, (1991)

[3]

Johnson E.S., Human exposure to 2,3,7,8-TCDD and risk of cancer, Crit Rev Toxicol, 21, pp. 451-463, (1992)

[4]

Bond G.G., McLaren E.A., Lipps T.E., Cook R.R., Update of mortality among chemical workers with potential exposure to the higher chlorinated dioxins, J Occup Med, 31, pp. 121-123, (1989)

[5]

Coggon D., Pannett B., Winter P., Mortality and incidence of cancer at four factories making phenoxy herbicides, Br J Ind Med, 48, pp. 173-178, (1991)

[6]

Fingerhut M.A., Halperin W.E., Marlow D.A., Piacitelli L.A., Honchar P.A., Sweeney M.H., Greife A.L., Dill P.A., Steenland K., Suruda A.J., Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin, N Engl J Med, 324, pp. 212-218, (1991)

[7]

Manz A., Berger J., Dwyer J.H., Flesch-Janys D., Nagel S., Waltsgott H., Cancer mortality among workers in chemical plant contaminated with dioxin, Lancet, 338, pp. 959-964, (1991)

[8]

Saracci R., Kogevinas M., Bertazzi P.A., Bueno De Mesquita B.H., Coggon D., Green L.M., Kauppinen T., L'Abbe K.A., Littorin M., Lynge E., Mathews J.D., Neuberger M., Osman J., Pearce N., Winkelman R., Cancer mortality in workers exposed to chloro- phenoxy herbicides and chlorophenols, Lancet, 338, pp. 1027-1032, (1991)

[9]

Hardell L., Sandstrom A., Case-control study: Soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols, Br J Cancer, 39, pp. 711-717, (1979)

[10]

Axelson O., Sundell L., Andersson K., Edling C., Hogstedt C., Kling H., Herbicide exposure and tumor mortality: An updated epidemiologic investigation on Swedish railroad workers, Scand J Work Environ Health, 6, pp. 73-79, (1980)

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