REPEATED D-1 RECEPTOR AGONIST TREATMENT BLOCKS COCAINE-INDUCED LOCOMOTOR-ACTIVITY AND C-FOS EXPRESSION

被引：17
作者：
ASIN, KE [1 ]
NIKKEL, AL [1 ]
WIRTSHAFTER, D [1 ]
机构：
[1] UNIV ILLINOIS,DEPT PSYCHOL,CHICAGO,IL 60680
来源：
BRAIN RESEARCH | 1994年 / 637卷 / 1-2期
关键词：
COCAINE; DOPAMINE D-1 RECEPTOR; C-FOS GENE EXPRESSION; SUBSENSITIVITY; A-77636;
D O I：
10.1016/0006-8993(94)91258-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Pretreatment of rats for 4 days with the selective dopamine D, receptor agonist A-77636 attenuated the ability of cocaine to induce locomotor hyperactivity and to stimulate the expression of the proto-oncogene c-fos in the striatum and nucleus accumbens. Our results suggest that repeated D-1 agonist treatment leads to subsensitivity of D-1 receptors involved in mediating some of the effects of cocaine on behavior and gene expression.
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收藏
页码：342 / 344
页数：3
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