EFFECT OF THE INHIBITOR OF CARNITINE-DEPENDENT METABOLISM OF MILDRONATE ON FATTY-ACID OXIDATION IN LIVER-MITOCHONDRIA OF INTACT RATS

被引：0

作者：

KAGAN, TI

SIMKHOVICH, BZ

KALVINS, IJ

LUKEVICS, EJ

机构：

来源：

VOPROSY MEDITSINSKOI KHIMII | 1991年 / 37卷 / 02期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Effect of antiischemic drug mildronate 3-(2,2,2-trimethylhydrazinium) propionate on oxidation of sodium octanoate and L-palmitoyl carnitine was studied in liver mitochondria of intact rats using polarographic procedure. After 10 days of administration of mildronate at a dose of 200 mg/kg per os oxidation of sodium octanoate was stimulated in liver mitochondria while the rate of L-palmitoyl carnitine oxidation was unaltered. The data obtained suggest that mildronate stimulated the carnitine-independent fatty acid oxidation which appears to occur as a compensation for inhibition of the carnitine-dependent oxidation by the drug.

引用

页码：44 / 46

页数：3

共 10 条

[1] CARNITINE - METABOLISM AND FUNCTIONS [J].

BREMER, J .

PHYSIOLOGICAL REVIEWS, 1983, 63 (04) :1420-1480

[2]

CLARKE PRH, 1981, J BIOL CHEM, V256, P9861

[3]

KOCHETOV GA, 1971, PRAKTICHESKOE RUKOVO, P309

[4]

KONDRASHOVA MN, 1981, BIOFIZIKA+, V26, P687

[5]

ROTENBERG YS, 1974, B EKSPER BIOL, P65

[6]

SHUTENKO ZV, 1988, THESIS TARTU, P5

[7]

SHUTENKO ZV, 1987, IZV AN LATVSSR, P102

[8]

SIIMKHOVICH BZ, 1987, KARDIOLOGIYA, P85

[9] 3-(2,2,2-TRIMETHYLHYDRAZINIUM)PROPIONATE (THP) - A NOVEL GAMMA-BUTYROBETAINE HYDROXYLASE INHIBITOR WITH CARDIOPROTECTIVE PROPERTIES [J].

SIMKHOVICH, BZ ;

SHUTENKO, ZV ;

MEIRENA, DV ;

KHAGI, KB ;

MEZAPUKE, RJ ;

MOLODCHINA, TN ;

KALVINS, IJ ;

LUKEVICS, E .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (02) :195-202

[10]

SIMKHOVICH BZ, 1988, VOPR MED KHIMII, P30

← 1 →