OSTEOARTHRITIS OF THE KNEE IN THE RABBIT PRODUCED BY IMMOBILIZATION - ATTEMPTS TO ACHIEVE A REPRODUCIBLE MODEL FOR STUDIES ON PATHOGENESIS AND THERAPY

被引：192

作者：

LANGENSKIOLD, A ^{[1
]}

MICHELSSON, JE ^{[1
]}

VIDEMAN, T ^{[1
]}

机构：

[1] ORTHOPAED HOSP,INVALID FDN,HELSINKI,FINLAND

来源：

ACTA ORTHOPAEDICA SCANDINAVICA | 1979年 / 50卷 / 01期

关键词：

Animal experiments; Immobilization; Knee; Osteoarthritis;

D O I：

10.3109/17453677909024083

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

In order to obtain a reproducible experimental model of osteoarthritis a method of immobilizing the rabbit's knee in extension by means of a plastic splint was developed. the right knees of the rabbits were immobilized for periods varying from 4 days to 24 weeks. With the left knees as controls the knees were studied in a variety of ways among these being radiography (126 rabbits), histological sections stained with Alcian Blue (88 rabbits), analysis of 35S-sulphate uptake (22 rabbits) and 35S-autoradiography (6 rabbits). In 27 rabbits the regaining of mobility after immobilization was studied. After 5-6 weeks of immobilization most of the knees showed moderate or severe changes including loss of articular cartilage and osteophyte formation. Immobilization of the rabbit's knee by this method provokes a fairly easily reproducible type of degenerative joint disease showing similarities to advanced osteoarthritis as seen in humans. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：1 / 14

页数：14

共 35 条

[1]

BENTLEY G, 1974, EXPT OSTEOARTHROSIS, P259

[2] OSTEOTOMY IN THE TREATMENT OF OSTEO-ARTHRITIS OF THE HIP [J].