AUTOREACTIVE T-CELL CLONES OF MHC CLASS-II SPECIFICITIES ARE PRODUCED DURING RESPONSES AGAINST FOREIGN ANTIGENS IN MAN

被引：0

作者：

TILKIN, AF ^{[1
]}

MICHON, J ^{[1
]}

JUY, D ^{[1
]}

KAYIBANDA, M ^{[1
]}

HENIN, Y ^{[1
]}

STERKERS, G ^{[1
]}

BETUEL, H ^{[1
]}

LEVY, JP ^{[1
]}

机构：

[1] CTR TRANSFUS REG LYON, F-69342 LYON, FRANCE

来源：

JOURNAL OF IMMUNOLOGY | 1987年 / 138卷 / 03期

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although the existence of autoreactive T cells has been widely reported in mice and in guinea pigs, a similar phenomenon is poorly documented in man. Here we report the study of three human autoreactive T cell clones isolated during immunization of HLA-DRw13 donors either against influenza A/Texas virus or against allogeneic cells. These clones are specific for autologous HLA-class II specificities either common to all HLA-DRw13 molecules or restricted to the HLA-DR products specific for the DW19 subtype of HLA-DRw13. They are also cytotoxic and they have the same specificity when tested for lytic activity or in proliferation assays. Furthermore, they are also able to help autologous B cells to polyclonally produce Ig. The possible implication of such clones in regulatory mechanisms involving HLA-class II molecules is discussed.

引用

页码：674 / 679

页数：6

共 38 条

[1] DEMONSTRATION AT THE SINGLE-CELL LEVEL OF THE EXISTENCE OF DISTINCT CLUSTERS OF EPITOPES IN 2 PREDEFINED HUMAN IA MOLECULAR SUBSETS [J].