EFFECTS OF THE ORGANOPHOSPHATE INSECTICIDE, MONOCROTOPHOS, ON ACETYLCHOLINESTERASE ACTIVITY IN THE NILE TILAPIA FISH (OREOCHROMIS-NILOTICUS) BRAIN

被引：13
作者：
THANGNIPON, W
THANGNIPON, W
LUANGPAIBOON, P
CHINABUT, S
机构：
[1] DEPT AGR, DIV AGR TOX SUBSTANCES, BANGKOK 10900, THAILAND
[2] AQUAT ANIM HLTH RES INST, DEPT FISHERIES, BANGKOK 10900, THAILAND
来源：
NEUROCHEMICAL RESEARCH | 1995年 / 20卷 / 05期
关键词：
ORGANOPHOSPHATE INSECTICIDE; MONOCROTOPHOS; ACETYLCHOLINESTERASE; OREOCHROMIS NILOTICUS; BRAIN;
D O I：
10.1007/BF01694540
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The neurotoxic effects of monocrotophos on the brain of the nile tilapia fish (Oreochromis niloticus) were examined, using a static bioassay under laboratory conditions. By probit analysis the 96 h LC(50) value of monocrotophos was 4.9 mg/l. After 96 h exposure to acute levels of monocrotophos, the brain acetylcholinesterase (AChE) activity decreased progressively as the concentration of monocrotophos increased. In addition, four weeks following transfer to toxicant-free water after exposure to 1 mg monocrotophos, nile tilapia fish brain regained 95% of control AChE activity. The results indicate that inhibition of AChE activity in fish exposed to monocrotophos may serve as an indicator of hazard due to application of this chemical in the natural environment.
引用
收藏
页码：587 / 591
页数：5
相关论文
共 34 条
[1]   MALATHION TOXICITY - INVIVO INHIBITION OF ACETYLCHOLINESTERASE IN THE FISH BRACHYDANIO-RERIO (CYPRINIDAE) [J].
ANSARI, BA ;
KUMAR, K .
TOXICOLOGY LETTERS, 1984, 20 (03) :283-287
[2]   ANTICHOLINESTERASE ACTION OF METHYL PARATHION, PARATHION AND AZINPHOSMETHYL IN MICE AND FISH - ONSET AND RECOVERY OF INHIBITION [J].
BENKE, GM ;
MURPHY, SD .
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1974, 12 (01) :117-122
[3]   COMPARATIVE TOXICITY, ANTICHOLINESTERASE ACTION AND METABOLISM OF METHYL PARATHION AND PARATHION IN SUNFISH AND MICE [J].
BENKE, GM ;
CHEEVER, KL ;
MIRER, FE ;
MURPHY, SD .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1974, 28 (01) :97-109
[4]  
CHIN YN, 1979, ENVIRON POLLUT, V18, P213
[5]   SHORT-TERM EFFECTS OF ORGANOPHOSPHATE PESTICIDES ON CHOLINESTERASES OF ESTUARINE FISHES AND PINK SHRIMP [J].
COPPAGE, DL ;
MATTHEWS, E .
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1974, 11 (05) :483-488
[6]  
Costa L. G., 1987, Toxicology of pesticides: experimental, clinical and regulatory perspectives., P77
[7]   A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].
ELLMAN, GL ;
COURTNEY, KD ;
ANDRES, V ;
FEATHERSTONE, RM .
BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&
[8]   RECOVERY OF CHOLINESTERASE ACTIVITY IN 5 AVIAN SPECIES EXPOSED TO DICROTOPHOS, AN ORGANO-PHOSPHORUS PESTICIDE [J].
FLEMING, WJ ;
GRUE, CE .
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 1981, 16 (02) :129-135
[9]   COMPARATIVE TOXICITY, CHOLINERGIC EFFECTS, AND TISSUE-LEVELS OF S,S,S,-TRI-N-BUTYL PHOSPHOROTRITHIOATE (DEF) TO CHANNEL CATFISH (ICTALURUS-PUNCTATUS) AND BLUE CRABS (CALLINECTES-SAPIDUS) [J].
HABIG, C ;
DIGIULIO, RT ;
NOMEIR, AA ;
ABOUDONIA, MB .
AQUATIC TOXICOLOGY, 1986, 9 (4-5) :193-206
[10]  
HOLLAND H. TOM, 1967, BULL ENVIRON CONTAM TOXICOL, V2, P156, DOI 10.1007/BF01684015
1234