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DOPAMINE FAVORS THE EMERGENCE OF LONG-TERM DEPRESSION VERSUS LONG-TERM POTENTIATION IN SLICES OF RAT PREFRONTAL CORTEX
被引:72
作者:
LAWTHO, D
DESCE, JM
CREPEL, F
机构:
[1] CNRS ERS 0100, Laboratoire de Neurobiologie et Neuropharmacologie du développement, Université de Paris-Sud
关键词:
SYNAPTIC PLASTICITY;
LONG-TERM DEPRESSION;
EXCITATORY TRANSMISSION;
DOPAMINE;
PREFRONTAL CORTEX;
NEUROMODULATION;
D O I:
10.1016/0304-3940(95)11414-R
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
In the present study, we have investigated possible interactions between dopamine and long-term changes in synaptic efficacy induced in layer V pyramidal cells by tetanization of afferents from layer I-II. In the absence of dopamine, we confirmed that high frequency stimulation of excitatory afferents induced long-term potentiation, long-term depression or no change. Inversely, in the presence of dopamine, we have found that the same tetanus led to long-term depression in synaptic transmission in a majority of cells, but no more long-term potentiation. These results suggest that in rat prefrontal cortex, dopamine may determine the direction of activity dependent changes in synaptic efficacy and therefore, plays a fundamental role in the physiology of this structure.
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页码:125 / 128
页数:4
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