NEW PLATINUM(II) COMPLEXES OF BETA-CYCLODEXTRIN DIAMINE DERIVATIVES AND THEIR ANTITUMOR-ACTIVITY

被引：19

作者：

CUCINOTTA, V

MANGANO, A

NOBILE, G

SANTORO, AM

VECCHIO, G

机构：

[1] UNIV CATANIA,IST PATOL GEN,CATANIA,ITALY

[2] CONSORZIO CATANIA RIC,CATANIA,ITALY

[3] CNR,IST STUDIO SOSTANZE NAT INTERESSE ALIMENTARE & CH,CATANIA,ITALY

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1993年 / 52卷 / 03期

关键词：

D O I：

10.1016/0162-0134(93)80039-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The new platinum(II) complexes of beta-cyclodextrin functionalized at the primary position with ethylenediamine or with propylenediamine were synthesized and characterized by mass spectrometry, electronic spectrophotometry, and multinuclear NMR spectroscopy. Platinum(II) complexation makes the cavity more asymmetric. These complexes were tested in vitro for their cytotoxic activity. The relevance of the low activity observed regarding the interaction between the cell and the cyclodextrin cavity is discussed.

引用

收藏

页码：183 / 190

页数：8

相关论文

共 17 条

[1] THE X-RAY CRYSTAL-STRUCTURE OF A 1-1 ADDUCT BETWEEN ALPHA-CYCLODEXTRIN AND CYCLOBUTANE-1,1-DICARBOXYLATODIAMMINEPLATINUM(II) [J].

ALSTON, DR ;

SLAWIN, AMZ ;

STODDART, JF ;

WILLIAMS, DJ .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1985, (22) :1602-1604

[2] THE BINDING OF CYCLOBUTANE-1,1-DICARBOXYLATODIAMMINEPLATINUM(II) BY ALPHA-CYCLODEXTRIN IN AQUEOUS-SOLUTION [J].

ALSTON, DR ;

LILLEY, TH ;

STODDART, JF .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1985, (22) :1600-1602

[3]

BONOMO RP, 1991, INORG CHEM, V3, P27

[4] EARLY CLINICAL-STUDIES WITH CIS-DIAMMINE-1,1-CYCLOBUTANE DICARBOXYLATE PLATINUM-II [J].

CALVERT, AH ;

HARLAND, SJ ;

NEWELL, DR ;

SIDDIK, ZH ;

JONES, AC ;

MCELWAIN, TJ ;

RAJU, S ;

WILTSHAW, E ;

SMITH, IE ;

BAKER, JM ;

PECKHAM, MJ ;

HARRAP, KR .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1982, 9 (03) :140-147

[5] CALORIMETRIC STUDIES OF THE INTERACTION OF 4-BIPHENYLACETIC ACID AND ITS BETA-CYCLODEXTRIN INCLUSION COMPOUND WITH LIPID MODEL MEMBRANE [J].

CASTELLI, F ;

PUGLISI, G ;

PIGNATELLO, R ;

GURRIERI, S .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1989, 52 (02) :115-121

[6] CYCLOPEPTIDE FUNCTIONALIZED BETA-CYCLODEXTRIN - A NEW CLASS OF POTENTIALLY ENZYME MIMICKING COMPOUNDS WITH 2 RECOGNITION SITES [J].

CUCINOTTA, V ;

DALESSANDRO, F ;

IMPELLIZZERI, G ;

PAPPALARDO, G ;

RIZZARELLI, E ;

VECCHIO, G .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (05) :293-294

[7]

GOODFELLOW RJ, 1987, MULTINUCLEAR NMR, P533

[8]

HACKER MP, 1984, PLATINUM COORDINATIO

[9] CIS-DIAMINEPLATINUM(II) COMPLEXES CONTAINING PHOSPHONO CARBOXYLATE LIGANDS AS ANTITUMOR AGENTS [J].

HOLLIS, LS ;

MILLER, AV ;

AMUNDSEN, AR ;

SCHURIG, JE ;

STERN, EW .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (01) :105-111

[10] 6-DEOXY-6-N-HISTAMINO-BETA-CYCLODEXTRIN COPPER(II) COMPLEX, A NEW ENANTIOSELECTIVE RECEPTOR FOR AROMATIC-AMINO-ACIDS [J].

IMPELLIZZERI, G ;

MACCARRONE, G ;

RIZZARELLI, E ;

VECCHIO, G ;

CORRADINI, R ;

MARCHELLI, R .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1991, 30 (10) :1348-1349