HUMANIZED ANTIBODIES (REPRINTED FROM TRENDS IN PHARMACOLOGICAL SCIENCES, VOL 14, PG 139-143, 1993)

被引：122

作者：

WINTER, G

HARRIS, WJ

机构：

[1] MRC, CTR PROT ENGN, CAMBRIDGE CB2 2QH, ENGLAND

[2] UNIV ABERDEEN MARISCHAL COLL, DEPT MOLEC & CELL BIOL, ABERDEEN AB9 1AS, SCOTLAND

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 06期

关键词：

D O I：

10.1016/0167-5699(93)90039-N

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hybridoma technology enabled rodent monoclonal antibodies to be created against human pathogens and cells, but these bad limited clinical utility. Protein engineering is now generating antibodies for treatment of infectious disease, autoimmune disease and cancer by 'humanizing' rodent antibodies. Humanized antibodies have improved pharmacokinetics, reduced immunogenicity and have been used to clinical advantage.

引用

页码：243 / 246

页数：4

共 33 条

[1]

ADAIR JR, 1992, IMMUNOL REV, V130, P1

[2]

ADAIR JR, 1992, BIOTECH GEN ENGN REV, V10, P1

[3]

ALLEN PM, 1985, J IMMUNOL, V135, P368

[4]

ANASETTI C, 1992, NOV AM SOC HAEM AN

[5] HIGH-LEVEL EXPRESSION OF A RECOMBINANT ANTIBODY FROM MYELOMA CELLS USING A GLUTAMINE-SYNTHETASE GENE AS AN AMPLIFIABLE SELECTABLE MARKER [J].

BEBBINGTON, CR ;

RENNER, G ;

THOMSON, S ;

KING, D ;

ABRAMS, D ;

YARRANTON, GT .

BIO-TECHNOLOGY, 1992, 10 (02) :169-175

[6] ESCHERICHIA-COLI SECRETION OF AN ACTIVE CHIMERIC ANTIBODY FRAGMENT [J].

BETTER, M ;

CHANG, CP ;

ROBINSON, RR ;

HORWITZ, AH .

SCIENCE, 1988, 240 (4855) :1041-1043

[7] THE IMMUNOGENICITY OF CHIMERIC ANTIBODIES [J].

BRUGGEMANN, M ;

WINTER, G ;

WALDMANN, H ;

NEUBERGER, MS .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (06) :2153-2157

[8] HUMANIZATION OF AN ANTI-P185HER2 ANTIBODY FOR HUMAN CANCER-THERAPY [J].

CARTER, P ;

PRESTA, L ;

GORMAN, CM ;

RIDGWAY, JBB ;

HENNER, D ;

WONG, WLT ;

ROWLAND, AM ;

KOTTS, C ;

CARVER, ME ;

SHEPARD, HM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4285-4289

[9] HIGH-LEVEL ESCHERICHIA-COLI EXPRESSION AND PRODUCTION OF A BIVALENT HUMANIZED ANTIBODY FRAGMENT [J].

CARTER, P ;

KELLEY, RF ;

RODRIGUES, ML ;

SNEDECOR, B ;

COVARRUBIAS, M ;

VELLIGAN, MD ;

WONG, WLT ;

ROWLAND, AM ;

KOTTS, CE ;

CARVER, ME ;

YANG, M ;

BOURELL, JH ;

SHEPARD, HM ;

HENNER, D .

BIO-TECHNOLOGY, 1992, 10 (02) :163-167

[10] CANONICAL STRUCTURES FOR THE HYPERVARIABLE REGIONS OF IMMUNOGLOBULINS [J].

CHOTHIA, C ;

LESK, AM .

JOURNAL OF MOLECULAR BIOLOGY, 1987, 196 (04) :901-917

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