SYNTHESIS OF A PEPTIDYL 2,2-DIFLUORO-3-AMINOPROPIONATE

被引：28

作者：

ANGELASTRO, MR ^{[1
]}

BEY, P ^{[1
]}

MEHDI, S ^{[1
]}

PEET, NP ^{[1
]}

机构：

[1] MARION MERRELL DOW RES INST,2110 E GALBRAITH RD,CINCINNATI,OH 45215

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(00)80220-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ethyl 3-(benzylamino)-2,2-difluoro-4-methylpentanoate (4) was prepared via a Reformatsky reaction of ethyl bromodifluoroacetate with the imine from isovaleraldehyde and benzylamine. N-Debenzylation of 4 gave amino ester 6, which was coupled to Boc.Ala.Ala.Pro.OH to provide a potential proteinase inhibitor.

引用

页码：1235 / 1238

页数：4

共 17 条

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