SYNTHESIS OF N-(ALPHA,ALPHA,ALPHA-TRI[F-18]FLUORO-M-TOLYL)PIPERAZINE - A POTENT SEROTONIN AGONIST

被引：20

作者：

ANGELINI, G

SPERANZA, M

WOLF, AP

SHIUE, CY

机构：

[1] CNR,IST CHIM NUCL,ROME,ITALY

[2] UNIV TUSCIA,VITERBO,ITALY

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1990年 / 28卷 / 12期

关键词：

D O I：

10.1002/jlcr.2580281213

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

N‐(α,α,α‐tri[18F]fluoro‐m‐tolyl)piperazine (6), a serotonin agonist, was synthesized from 3‐nitro‐α,α,α‐trichlorotoluene (1) and H[18F] + Sb2O3 in four steps in 27% overall radiochemical yield in a synthesis time of ˜ 3 hours. Copyright © 1990 John Wiley & Sons, Ltd.

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页码：1441 / 1448

页数：8

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