FREE RADICAL-MEDIATED CHAIN OXIDATION OF LOW-DENSITY-LIPOPROTEIN AND ITS SYNERGISTIC INHIBITION BY VITAMIN-E AND VITAMIN-C

被引：292

作者：

SATO, K

NIKI, E

SHIMASAKI, H

机构：

[1] UNIV TOKYO, FAC ENGN, DEPT REACT CHEM, TOKYO 113, JAPAN

[2] TEIKYO UNIV, SCH MED, DEPT BIOCHEM, TOKYO 173, JAPAN

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1990年 / 279卷 / 02期

关键词：

D O I：

10.1016/0003-9861(90)90508-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The oxidation of human low density lipoprotein (LDL) initiated by free radical initiator and its inhibition by vitamin E and water-soluble antioxidants have been studied. It was found that the kinetic chain length was considerably larger than 1, suggesting that LDL was oxidized by a free radical chain mechanism. Vitamin E acted as a lipophilic chain-breaking antioxidant Water-soluble chain-breaking antioxidants such as ascorbic acid and uric acid suppressed the oxidation of LDL initiated by aqueous radicals but they could not scavenge lipophilic radicals within LDL to break the chain propagation. Ascorbic acid acted as a synergistic antioxidant in conjunction with vitamin E. © 1990.

引用

页码：402 / 405

页数：4

共 31 条

[1] AUTOXIDATION OF MICELLES AND MODEL MEMBRANES - QUANTITATIVE KINETIC MEASUREMENTS CAN BE MADE BY USING EITHER WATER-SOLUBLE OR LIPID-SOLUBLE INITIATORS WITH WATER-SOLUBLE OR LIPID-SOLUBLE CHAIN-BREAKING ANTIOXIDANTS [J].