CHROMOSOME ABERRATIONS INDUCED BY MYLERAN IN HUMAN LEUCOCYTES IN VITRO

1. The alkylating agent Myleran (Busulfan) is often used for therapy in chronic myeloic leukemia. The agent frequently causes chromosome aberrations in human lymphcytes in vitro. 2. Aberrations of gap-type, of chromatid and chromosome type often occur together in the same metaphase. Exchanges are remarkably rare. 3. Myleran-induced aberrations seem to be distributed non-random among cells. The relation between dose of the agent and its cytogenetic effectivity is apparent. 4. The agent seems to be most effective in the first half of interphase. 5. The results are discussed; the possibility of induction of chromosome aberrations by Myleran-therapy is evident. © 1969 Springer-Verlag.