FLUOROGENIC N-NITROSOAMIDES - ACTIVE-SITE LABELING REAGENTS FOR CHYMOTRYPSIN-LIKE PROTEASES

被引：1
作者：
LI, M
WHITE, EH
机构：
[1] Department of Chemistry, The Johns Hopkins University, Baltimore
来源：
BIOCONJUGATE CHEMISTRY | 1994年 / 5卷 / 05期
关键词：
D O I：
10.1021/bc00029a012
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Two fluorogenic N-nitrosoamides, N-nitroso-N-((7-methoxycoumarin-4-yl)methyl)-N'-isobutyrylalaninamide (6a) and N-nitroso-N-((6-methoxyquinolin-2-yl)met (6b), were synthesized. Both N-nitrosoamides inhibited alpha-chymotrypsin irreversibly; they show promise as labeling reagents for the active sites of chymotrypsin-like proteases.
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页码：454 / 458
页数：5
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