THE MURINE NPY-1 RECEPTOR GENE - STRUCTURE AND DELINEATION OF TISSUE-SPECIFIC EXPRESSION

被引：83

作者：

EVA, C ^{[1
]}

OBERTO, A ^{[1
]}

SPRENGEL, R ^{[1
]}

GENAZZANI, E ^{[1
]}

机构：

[1] UNIV HEIDELBERG, ZENTRUM MOLEK BIOL, W-6900 HEIDELBERG, GERMANY

来源：

FEBS LETTERS | 1992年 / 314卷 / 03期

关键词：

G-PROTEIN RECEPTOR; NEUROPEPTIDE-Y; NEUROPEPTIDE RECEPTOR; GENE STRUCTURE; GENE EXPRESSION;

D O I：

10.1016/0014-5793(92)81490-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The murine gene for the NPY-1 receptor subtype for neuropeptide Y was characterized by DNA sequencing and expression studies. It comprises three exons with a 6,400 bp 5'-untranslated and a 80 bp internal intronic sequence. The 5'-flanking region of this gene lacks TATA or CCAAT consensus sequences in the proximity to the multiple transcription initiation sites. A 1,300 bp genomic fragment of the 5'-flanking region drives the expression of the lacZ reporter gene in NG108-15 cells and primary cultured neurons but not in glial and human embryonic kidney cells. In addition, it contains consensus sequences for various transcription factors including cAMP- and glucocorticoid-responsive elements.

引用

页码：285 / 288

页数：4

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