LIPID-PEROXIDATION AND HOMOCYSTEINE INDUCED TOXICITY

被引：57
|
作者：
JONES, BG [1 ]
ROSE, FA [1 ]
TUDBALL, N [1 ]
机构：
[1] UNIV WALES COLL CARDIFF,DEPT BIOCHEM,MUSEUM AVE,POB 903,CARDIFF CF1 1ST,WALES
来源：
ATHEROSCLEROSIS | 1994年 / 105卷 / 02期
关键词：
LIPID PEROXIDATION; HOMOCYSTEINE; ENDOTHELIAL CELLS; H2O2; HO-CENTER-DOT;
D O I：
10.1016/0021-9150(94)90046-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Homocysteine induced toxicity has been examined in cultures of human umbilical vein endothelial cells. The toxic effects of the amino acid alone and the amino acid plus Cu2+ could be prevented by catalase and decreased by desferal, when either was present in the culture medium. When desferal was allowed to accumulate intracellularly, no significant protection from homocysteine induced toxicity was observed. Even though lipid peroxidation accompanied the toxicity induced by homocysteine and homocysteine plus Cu2+, inhibition of lipid peroxidation in either case had no effect on cell viability. The significance of these results is discussed.
引用
收藏
页码：165 / 170
页数：6
相关论文
共 50 条
  • [21] CAPSAICIN ACTION MODULATES LIPID-PEROXIDATION INDUCED BY DIFFERENT IRRITANTS
    DE, AK
    GHOSH, JJ
    PHYTOTHERAPY RESEARCH, 1993, 7 (04) : 273 - 277
  • [22] HOMOCYSTEINE INDUCES IRON-CATALYZED LIPID-PEROXIDATION OF LOW-DENSITY-LIPOPROTEIN THAT IS PREVENTED BY ALPHA-TOCOPHEROL
    HIRANO, K
    OGIHARA, T
    MIKI, M
    YASUDA, H
    TAMAI, H
    KAWAMURA, N
    MINO, M
    FREE RADICAL RESEARCH, 1994, 21 (05) : 267 - 276
  • [23] TOXICITY OF ALDEHYDE PRODUCTS OF LIPID-PEROXIDATION TO ADULT SCHISTOSOMA-INTERCALATUM INVITRO
    BARRETT, J
    INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1991, 21 (08) : 975 - 977
  • [24] RETARDATION OF CELL AGING BY LIPID-PEROXIDATION
    ZHENG, RL
    ZHENG, TS
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 1992, 115 (01) : 59 - 62
  • [25] DIFFERENT STRESSORS AND BLOOD LIPID-PEROXIDATION
    LAVICKY, J
    RASKOVA, H
    ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 1991, 41-2 (08): : 793 - 796
  • [26] EFFECTS OF ALUMINUM ON BRAIN LIPID-PEROXIDATION
    FRAGA, CG
    OTEIZA, PI
    GOLUB, MS
    GERSHWIN, ME
    KEEN, CL
    TOXICOLOGY LETTERS, 1990, 51 (02) : 213 - 219
  • [27] Lipid peroxidation and homocysteine levels in Behcet's disease
    Mungan, A. Gorkem
    Can, Murat
    Acikgoz, Serefden
    Esturk, Emel
    Altinyazar, Cevdet
    CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2006, 44 (09) : 1115 - 1118
  • [28] FERRITIN, LIPID-PEROXIDATION AND REDOXCYCLING XENOBIOTICS
    WINTERBOURN, CC
    VILE, GF
    MONTEIRO, HP
    FREE RADICAL RESEARCH COMMUNICATIONS, 1991, 12-3 : 107 - 114
  • [29] LIPID-PEROXIDATION AND MTDNA DEGENERATION - A HYPOTHESIS
    HRUSZKEWYCZ, AM
    MUTATION RESEARCH, 1992, 275 (3-6): : 243 - 248
  • [30] POSSIBLE SOURCES OF IRON FOR LIPID-PEROXIDATION
    MINOTTI, G
    DIGENNARO, M
    DUGO, D
    GRANONE, P
    FREE RADICAL RESEARCH COMMUNICATIONS, 1991, 12-3 : 99 - 106
12345