AN IMMUNOHISTOCHEMICAL STUDY OF BONE MORPHOGENETIC PROTEIN IN PLEOMORPHIC ADENOMA OF THE SALIVARY-GLAND

被引：20

作者：

LIANJIA, Y ^{[1
]}

YAN, J ^{[1
]}

HITOSHI, N ^{[1
]}

SHINICHIRO, S ^{[1
]}

AKIHIDE, K ^{[1
]}

MASAHIKO, M ^{[1
]}

机构：

[1] ASAHI UNIV,SCH DENT,DEPT ORAL SURG,GIFU 50102,JAPAN

来源：

VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY | 1993年 / 422卷 / 06期

关键词：

PLEOMORPHIC ADENOMA; BONE MORPHOGENETIC PROTEIN; IMMUNOHISTOCHEMISTRY;

D O I：

10.1007/BF01606451

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Bone morphogenetic protein (BMP) is a potent induction factor for new bone formation including heterotopic chondro-ossification in soft tissues. The immunohistochemical reaction for BMP was studied in 23 cases of pleomorphic adenoma of salivary gland by using a monoclonal antibody produced by hybridoma technique. Positive BMP immunoreactivity was seen in 87% of tumours. Immunohistochemical expression of BMP was observed in modified myoepithelial cells (88% cases), luminal tumour cells of tubulo-ductal structures (78% cases) and chondroid cells in hyaline tissue (22% cases). The authors concluded that the simultaneous presence of glycosaminoglycans as matrix substance and S-100 protein for calcium signalling are associated with BMP-mediated cellular activity of modified myoepithelial cells in the formation of chondroid structures in pleomorphic adenomas of the salivary glands.

引用

页码：439 / 443

页数：5

共 26 条

[1] IDENTIFICATION OF TRANSFORMING GROWTH-FACTOR-BETA FAMILY MEMBERS PRESENT IN BONE-INDUCTIVE PROTEIN PURIFIED FROM BOVINE BONE [J].