GENES, VIRUSES AND NEURODEVELOPMENTAL SCHIZOPHRENIA

被引：61

作者：

MURRAY, RM ^{[1
]}

JONES, P ^{[1
]}

OCALLAGHAN, E ^{[1
]}

TAKEI, N ^{[1
]}

SHAM, P ^{[1
]}

机构：

[1] KINGS COLL HOSP,LONDON SE5 8AF,ENGLAND

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 1992年 / 26卷 / 04期

关键词：

D O I：

10.1016/0022-3956(92)90029-N

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Recent neuroimaging and neuropathological studies suggest a developmental origin for schizophrenia. Some cases may, therefore, be caused by a genetic defect in the specification of brain development. Early environmental hazards such as obstetric complications, and maternal exposure during pregnancy to influenza epidemics, have also been found to increase the risk of later schizophrenia. The relationship between the prevalence of influenza and birth date has been found more consistently for female than male schizophrenics. Female schizophrenia is also associated with a higher risk of schizophrenia in first degree relatives. This raises the question of whether part of the genetic predisposition to schizophrenia may comprise an abnormal reaction to maternal influenza.

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页码：225 / 235

页数：11

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