ANTIULCEROGENIC ACTIVITY OF AESCINE IN DIFFERENT EXPERIMENTAL-MODELS

被引：74
作者：
MARHUENDA, E [1 ]
MARTIN, MJ [1 ]
DELALASTRA, CA [1 ]
机构：
[1] FAC FARM SEVILLA, DEPT FARM & TECNOL FARMACEUT, GREGORIA SANTA TERESA S-N, E-41012 SEVILLE, SPAIN
来源：
PHYTOTHERAPY RESEARCH | 1993年 / 7卷 / 01期
关键词：
AESCINE; RANITIDINE; CARBENOXOLONE; ANTIULCEROGENIC;
D O I：
10.1002/ptr.2650070105
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The antiulcerogenic effect of aescine was studied on cold restraint, pylorus-ligated and absolute ethanol induced ulcers in comparison to ranitidine and carbenoxolone. Gastric mucus output, total protein and hexosamines content were measured. In pyloric-ligated animals, acidity, as well as biochemical assay of pepsin, histamine, sodium and potassium electrolytes were also determined. Oral treatment with aescine was found to be effective in the prevention of gastric ulceration induced by absolute ethanol, although mucus secretion was not enhanced. In pyloric-ligated animals aescine showed a considerable reduction in the number and severity of ulcers. A significant reduction in gastric secretion was also observed.
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页码：13 / 16
页数：4
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