Statistical analysis of the relationship between IL-10 gene promoter polymorphisms and the development of coronary artery disease

被引：3

作者：

Wu, L. ^{[1
]}

Zhao, M. H. ^{[1
]}

Geng, G. Y. ^{[1
]}

Mao, L. ^{[1
]}

Liu, H. J. ^{[1
]}

机构：

[1] Zhengzhou Peoples Hosp, Dept Cardiol, Zhengzhou, Henan, Peoples R China

来源：

GENETICS AND MOLECULAR RESEARCH | 2016年 / 15卷 / 04期

关键词：

IL-10; -1082A/G; -592A/C; Polymorphism; CAD;

D O I：

10.4238/gmr15047823

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here, we conducted a case-control study to investigate the association between IL-10 gene polymorphisms and development of CAD in a Chinese population. A total of 220 patients with CAD and 236 control subjects who visited the Zhengzhou People's Hospital between May 2012 and June 2014 were selected for this study. The IL-10-1082A/G and -592A/C polymorphisms were genotyped by polymerase chain reaction coupled with restriction fragment length polymorphism. The chi-squared test revealed a significant difference in the distributions of the IL-10-1082A/G genotypes (chi(2) = 6.32, P = 0.04). This data was then statistically analyzed by logistic regression analysis; we observed revealed that the CC genotype of IL-10-1082A/G had a higher risk of CAD in comparison to the AA genotype (OR = 2.09, 95%CI = 1.11-3.97). Moreover, the C allele of IL-10-1082A/G had a 1.39 fold risk of CAD when compared with (OR = 1.39, 95% CI = 1.061.82). We did not observe any significant correlations between the IL-10-592A/C genetic variation and susceptibility to CAD. In conclusion, our study suggests that the IL-10-1082A/G genetic variation could influence the development of CAD in a Chinese population.

引用

页数：7

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