OXIDANTS AND ANTIOXIDANTS - STATE-OF-THE-ART

被引:428
作者
BAST, A
HAENEN, GRMM
DOELMAN, CJA
机构
[1] Department of Pharmacochemistry, Vrije Universiteit, Amsterdam
关键词
D O I
10.1016/0002-9343(91)90278-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Reactive oxygen species are regarded as merely pernicious. This is incorrect for they play a pivotal role in many physiologic reactions, such as cytochrome P450-mediated oxidations, regulation of the tone of smooth muscle, and killing of microorganisms. An imbalance in oxidant-antioxidant activity is involved in many free radical-mediated pathologies, e.g., ischemia-reperfusion and asthma. In an attempt to alleviate these pathologies with antioxidants, it should be noted that these compounds are neither specific nor mere antioxidants. Associated with antioxidant activity is a pro-oxidant action. In the development of new antioxidant therapies, the important question of how these drugs are incorporated in or commensurate with existing integrated physiologic radical-defense systems should be addressed.
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页码:S2 / S13
页数:12
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