SUPPRESSION OF INTERLEUKIN-2 MEDIATED LYMPHOCYTE-T BLASTOGENESIS BY BOVINE UTERINE SECRETIONS

被引：18
作者：
SEGERSON, EC
GUNSETT, FC
机构：
[1] Department of Animal Science, North Carolina A&T State University, Greensboro
来源：
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1990年 / 22卷 / 3-4期
关键词：
Bovine; interleukin‐2; lymphocyte suppression; uterine secretions;
D O I：
10.1111/j.1600-0897.1990.tb00653.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
ABSTRACT: Uterine luminal protein (ULP) secretions collected on day 17 of bovine pregnancy contain high (≥248 kDa)‐ and low (7, 21.0, and ≥72 kDa)‐molecular weight (Mr) components that suppressed incorporation of thymidine into both phytohemagglutinin (PHA)‐stimulated and interleukin‐2 (IL‐2)‐stimulated bovine lymphocytes. The pattern of suppressor activity for ULP was similar for both PHA and IL‐2 cultures. For IL‐2‐treated lymphocytes (2 × 104/culture well), mean percentage of control (no test protein) values for 8 and 32 (xg/ml of high Mr ULP were 94.6% and 4.5%, respectively; whereas, mean values for 8 and 64 μg/ml of combined low Mr ULP components were 51.2% and 5.5%, respectively. The data indicate that specific bovine ULP components may locally affect T‐lymphocyte function by altering some facet of the IL‐2 activation system. 1990 Munksgaard
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页码：117 / 123
页数：7
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