TRYPANOSOMA-GAMBIENSE - MEMBRANE-TRANSPORT OF AMINO-ACIDS

Trypanosoma gambiense absorbed 14C-labeled lysine, arginine, glutamate, phenylalanine, methionine, threonine, glycine, and alanine by mediated transport systems. The interactions of these compounds as inhibitors or stimulators formed complex patterns of uptake which suggested the presence of five binding and/or transport loci: Locus A bound glutamate, arginine, and lysine, and the binding of glutamate or arginine stimulated the transport of lysine. Locus B transported threonine, glycine, and alanine and appeared to be partially sensitive to ouabain and Na+. Locus C transported glutamate, locus D transported phenylalanine and methionine, and locus E transported lysine and arginine. © 1979.