Epigenetic synthetic lethality in ovarian clear cell carcinoma: EZH2 and ARID1A mutations

被引：21

作者：

Bitler, Benjamin G. ^{[1
]}

Aird, Katherine M. ^{[1
]}

Zhang, Rugang ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Gene Express & Regulat, 3601 Spruce St, Philadelphia, PA 19104 USA

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ARID1A; EZH2; ovarian cancer; SWI/SNF chromatin-remodeling complex; synthetic lethality;

D O I：

10.1080/23723556.2015.1032476

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The components of the Switch/Sucrose non-fermentable (SWI/SNF) complex are mutated in approximately 20% of human cancers. The A/T-rich interacting domain 1A (ARID1A) subunit has one of the highest mutation rates. Most notably, ARID1A is mutated in over 50% of ovarian clear cell carcinomas (OCCCs). We reported that inhibition of enhancer of zeste homology 2 (EZH2) is synthetically lethal in ARID1A-mutated OCCC.

引用

页数：3

共 10 条

[1] Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers [J].

Bitler, Benjamin G. ;

Aird, Katherine M. ;

Garipov, Azat ;

Li, Hua ;

Amatangelo, Michael ;

Kossenkov, Andrew V. ;

Schultz, David C. ;

Liu, Qin ;

Shih, Ie-Ming ;

Conejo-Garcia, Jose R. ;

Speicher, David W. ;

Zhang, Rugang .

NATURE MEDICINE, 2015, 21 (03) :231-+

[2] Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling [J].

Chandler, Ronald L. ;

Damrauer, Jeffrey S. ;

Raab, Jesse R. ;

Schisler, Jonathan C. ;

Wilkerson, Matthew D. ;

Didion, John P. ;

Starmer, Joshua ;

Serber, Daniel ;

Yee, Della ;

Xiong, Jessie ;

Darr, David B. ;

de Villena, Fernando Pardo-Manuel ;

Kim, William Y. ;

Magnuson, Terry .

NATURE COMMUNICATIONS, 2015, 6

[3] Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma [J].

Jones, Sian ;

Wang, Tian-Li ;

Shih, Ie-Ming ;

Mao, Tsui-Lien ;

Nakayama, Kentaro ;

Roden, Richard ;

Glas, Ruth ;

Slamon, Dennis ;

Diaz, Luis A., Jr. ;

Vogelstein, Bert ;

Kinzler, Kenneth W. ;

Velculescu, Victor E. ;

Papadopoulos, Nickolas .

SCIENCE, 2010, 330 (6001) :228-231

[4] The concept of synthetic lethality in the context of anticancer therapy [J].

Kaelin, WG .

NATURE REVIEWS CANCER, 2005, 5 (09) :689-698

[5] Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2 [J].

Knutson, Sarah K. ;

Warholic, Natalie M. ;

Wigle, Tim J. ;

Klaus, Christine R. ;

Allain, Christina J. ;

Raimondi, Alejandra ;

Scott, Margaret Porter ;

Chesworth, Richard ;

Moyer, Mikel P. ;

Copeland, Robert A. ;

Richon, Victoria M. ;

Pollock, Roy M. ;

Kuntz, Kevin W. ;

Keilhack, Heike .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (19) :7922-7927

[6] Discovery and saturation analysis of cancer genes across 21 tumour types [J].

Lawrence, Michael S. ;

Stojanov, Petar ;

Mermel, Craig H. ;

Robinson, James T. ;

Garraway, Levi A. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Gabriel, Stacey B. ;

Lander, Eric S. ;

Getz, Gad .

NATURE, 2014, 505 (7484) :495-+

[7] EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations [J].

McCabe, Michael T. ;

Ott, Heidi M. ;

Ganji, Gopinath ;

Korenchuk, Susan ;

Thompson, Christine ;

Van Aller, Glenn S. ;

Liu, Yan ;

Graves, Alan P. ;

Della Pietra, Anthony, III ;

Diaz, Elsie ;

LaFrance, Louis V. ;

Mellinger, Mark ;

Duquenne, Celine ;

Tian, Xinrong ;

Kruger, Ryan G. ;

McHugh, Charles F. ;

Brandt, Martin ;

Miller, William H. ;

Dhanak, Dashyant ;

Verma, Sharad K. ;

Tummino, Peter J. ;

Creasy, Caretha L. .

NATURE, 2012, 492 (7427) :108-+

[8] Expression of p270 (ARID1A), a component of human SWI/SNF complexes, in human tumors [J].

Wang, XM ;

Nagl, NG ;

Flowers, S ;

Zweitzig, D ;

Dallas, PB ;

Moran, E .

INTERNATIONAL JOURNAL OF CANCER, 2004, 112 (04) :636-642

[9] ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas [J].

Wiegand, Kimberly C. ;

Shah, Sohrab P. ;

Al-Agha, Osama M. ;

Zhao, Yongjun ;

Tse, Kane ;

Zeng, Thomas ;

Senz, Janine ;

McConechy, Melissa K. ;

Anglesio, Michael S. ;

Kalloger, Steve E. ;

Yang, Winnie ;

Heravi-Moussavi, Alireza ;

Giuliany, Ryan ;

Chow, Christine ;

Fee, John ;

Zayed, Abdalnasser ;

Prentice, Leah ;

Melnyk, Nataliya ;

Turashvili, Gulisa ;

Delaney, Allen D. ;

Madore, Jason ;

Yip, Stephen ;

McPherson, Andrew W. ;

Ha, Gavin ;

Bell, Lynda ;

Fereday, Sian ;

Tam, Angela ;

Galletta, Laura ;

Tonin, Patricia N. ;

Provencher, Diane ;

Miller, Dianne ;

Jones, Steven J. M. ;

Moore, Richard A. ;

Morin, Gregg B. ;

Oloumi, Arusha ;

Boyd, Niki ;

Aparicio, Samuel A. ;

Shih, Ie-Ming ;

Mes-Masson, Anne-Marie ;

Bowtell, David D. ;

Hirst, Martin ;

Gilks, Blake ;

Marra, Marco A. ;

Huntsman, David G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (16) :1532-1543

[10] Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation [J].

Wilson, Boris G. ;

Wang, Xi ;

Shen, Xiaohua ;

McKenna, Elizabeth S. ;

Lemieux, Madeleine E. ;

Cho, Yoon-Jae ;

Koellhoffer, Edward C. ;

Pomeroy, Scott L. ;

Orkin, Stuart H. ;

Roberts, Charles W. M. .

CANCER CELL, 2010, 18 (04) :316-328

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